Upstream Processing

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Comprehensive risk assessment framework

Biochemicals/Raw Materials

Buffer and Solution Mixing-Time Validation: A Risk-Assessment Framework for Analysts Using Matrix and Bracketing Approaches Buffer and Solution Mixing-Time Validation: A Risk-Assessment Framework for Analysts Using Matrix and Bracketing Approaches

+6

byNaveenganesh Muralidharan, Leya S. Roseand 6 more

Jan 29, 2025

Lessons in Bioreactor Scale-Up, Part 5: Theoretical and Empirical Correlations for Predicting the Mass-Transfer Coefficient in Stirred-Tank Bioreactors Lessons in Bioreactor Scale-Up, Part 5: Theoretical and Empirical Correlations for Predicting the Mass-Transfer Coefficient in Stirred-Tank Bioreactors

byMuhammad Arshad Chaudhry

Jan 29, 2025

scientists on greenhouse

Emerging Therapeutics

Recombinant Human Collagen: Plant-Based Production Addresses Growing Demand for a Vegan Option Recombinant Human Collagen: Plant-Based Production Addresses Growing Demand for a Vegan Option

Jan 29, 2025

BioProcess International Upstream Production January-February 2025

Upstream Processing

January-February 2025 January-February 2025

Jan 27, 2025

Croda Pharma Ask the Expert

Sponsored Content

Introducing Super Refined™ Poloxamer 188: Optimized for Mammalian Cell Culture with Exceptional Batch-to-Batch Consistency Introducing Super Refined™ Poloxamer 188: Optimized for Mammalian Cell Culture with Exceptional Batch-to-Batch Consistency

byBPI Contributor

Oct 29, 2024

1 Hr View

A Scale-Up/-Down Platform for Fast-Paced Upstream Process Development of rAAV-Based Gene Therapies A Scale-Up/-Down Platform for Fast-Paced Upstream Process Development of rAAV-Based Gene Therapies

byTereza Pavlištová, Maria João Alves Correiaand 5 more

Oct 17, 2024

mass-transfer steps

Lessons in Bioreactor Scale-Up, Part 4: Physiochemical Factors Affecting Oxygen Transfer and the Volumetric Mass-Transfer Coefficient in Stirred Tanks

Lessons in Bioreactor Scale-Up, Part 4: Physiochemical Factors Affecting Oxygen Transfer and the Volumetric Mass-Transfer Coefficient in Stirred Tanks

byMuhammad Arshad Chaudhry

Repligen special report

Sponsored Content

Process Intensification: Overcoming the Inefficiencies of Traditional Fed Batch in Upstream Cell Culture

Process Intensification: Overcoming the Inefficiencies of Traditional Fed Batch in Upstream Cell Culture

CPC AseptiQuik

Sponsored Content

Maintaining Sterility Through CGT Processing and Cryopreservation

Maintaining Sterility Through CGT Processing and Cryopreservation

byBPI Contributor

Sartorius

Sponsored Content

Building Reliability Into Scale-Up: Targeted Optimization for AAV Production

Building Reliability Into Scale-Up: Targeted Optimization for AAV Production

byBPI Contributor

Lonza Biologics webinar slide 1

Sponsored Content

Process Intensification Through Perfused N-1 Bioreactor

Process Intensification Through Perfused N-1 Bioreactor

byBPI Contributor

bioreactor

Lessons in Bioreactor Scale-Up: Part 3 — Experimental Determination and Application of Oxygen Mass- Transfer Rate, Mass-Transfer Coefficient, and Oxygen-Uptake Rate

Lessons in Bioreactor Scale-Up — Part 3: Experimental Determination and Application of Oxygen Mass- Transfer Rate, Mass-Transfer Coefficient, and Oxygen-Uptake Rate

byMuhammad Arshad Chaudhry

digital hand

Expression Platforms

Application of Omics Technologies: Creating Next-Generation CHO Expression Platforms

Application of Omics Technologies: Creating Next-Generation CHO Expression Platforms

byPeter M. O’Callaghan, Alessandro Di Cara

September 2024

Upstream Processing

Sponsored Content

Optimizing Perfusion Parameters for CAR-T Cells: Intensified Production in the Ambr 250 High-Throughput Bioreactor (Webcast Recap)

Optimizing Perfusion Parameters for CAR-T Cells: Intensified Production in the Ambr 250 High-Throughput Bioreactor (Webcast Recap)

BPI Theater panelists

Expression Platforms

Improving Expression and Manufacturing of Novel Biologics

Improving Expression and Manufacturing of Novel Biologics

byBrian Gazaille

BioProcess International July-August 2024 cover

Expression Platforms

July-August 2024

July-August 2024

BPI Theater Interview: Nick Jackowetz, Senior Vice President and Principal Scientist, Hydrosome Labs

BPI Theater Interview: Nick Jackowetz, Senior Vice President and Principal Scientist, Hydrosome Labs

turbulent flow image

Lessons in Bioreactor Scale-Up, Part 2: A Refresher on Fluid Flow and Mixing

Lessons in Bioreactor Scale-Up, Part 2: A Refresher on Fluid Flow and Mixing

byMuhammad Arshad Chaudhry

Sponsored Content

Empowering Biologic Breakthroughs: Transforming Tomorrow’s Healthcare Landscape Through Microbial-Based Development and Manufacturing

Empowering Biologic Breakthroughs: Transforming Tomorrow’s Healthcare Landscape Through Microbial-Based Development and Manufacturing

byRebekka Wuester

Cell Culture Media

Development of Advanced Feed Media and Supplements (Webcast Recap)

Development of Advanced Feed Media and Supplements (Webcast Recap)

byYaron Silberberg

Bioreactor

Lessons in Bioreactor Scale-Up: Part 1 — Exploring Introductory Principles

Lessons in Bioreactor Scale-Up: Part 1 — Exploring Introductory Principles

byMuhammad Arshad Chaudhry

Characterizing Oxygen Mass Transfer and Shear During Cell Culture: Calculating the Maximum Cell Density Supported By a 20,000-Liter Stirred-Tank Bioreactor

Characterizing Oxygen Mass Transfer and Shear During Cell Culture: Calculating the Maximum Cell Density Supported By a 20,000-Liter Stirred-Tank Bioreactor

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byNaveenganesh Muralidharan, Emma Bolducand 1 more

Sponsored Content

Expansion into Late Drug Discovery and Early Development

Expansion into Late Drug Discovery and Early Development

byDerrick Katayama

Using Fed-Batch Intensification To Increase Expression Titer During Biologics Manufacturing

Sponsored Content

Using Fed-Batch Intensification To Increase Expression Titer During Biologics Manufacturing

Using Fed-Batch Intensification To Increase Expression Titer During Biologics Manufacturing

byRuth Rowland-Jones

Introduction: The Next Big Thing Could Be Disruptive

Expression Platforms

Introduction: The Next Big Thing Could Be Disruptive

Introduction: The Next Big Thing Could Be Disruptive

Reinventing How Drugs Are Invented: Making a Case for Simplicity in Drug Development and Production

Expression Platforms

Reinventing How Drugs Are Invented: Making a Case for Simplicity in Drug Development and Production

Reinventing How Drugs Are Invented: Making a Case for Simplicity in Drug Development and Production

Leveraging Plant-Based Protein Expression: Implications for Biomanufacturing and Biodefense

Expression Platforms

Leveraging Plant-Based Protein Expression: Implications for Biomanufacturing and Biodefense

Leveraging Plant-Based Protein Expression: Implications for Biomanufacturing and Biodefense

byBrian Gazaille, Don Stewart

Designer Cells for In Vivo Expression of Therapeutic Proteins: Emerging Applications Based on Gene Circuits

Expression Platforms

Designer Cells for In Vivo Expression of Therapeutic Proteins: Emerging Applications Based on Gene Circuits

Designer Cells for In Vivo Expression of Therapeutic Proteins: Emerging Applications Based on Gene Circuits

byBrian Gazaille, Martin Fussenegger

Bispecific Antibodies Unleashed

Sponsored Content

Bispecific Antibodies Unleashed

Bispecific Antibodies Unleashed

byBPI Contributor

November-December 2023 Product Development

Expression Platforms

November-December 2023

November-December 2023

Working Toward an AAV Platform: Challenges, Threats, and Opportunities

Sponsored Content

Working Toward an AAV Platform: Challenges, Threats, and Opportunities

Working Toward an AAV Platform: Challenges, Threats, and Opportunities

+1

byMégane Denu, Quentin Bazotand 1 more

A Breakthrough AAV Enhancer to Improve Titers and Reduce Production Costs with Any Serotype, Suspension HEK Cell Type, and Transfection Reagent

Sponsored Content

A Breakthrough AAV Enhancer to Improve Titers and Reduce Production Costs with Any Serotype, Suspension HEK Cell Type, and Transfection Reagent

A Breakthrough AAV Enhancer to Improve Titers and Reduce Production Costs with Any Serotype, Suspension HEK Cell Type, and Transfection Reagent

byBPI Contributor

Not Your Typical CDMO: Comprehensive Cell Solutions

Sponsored Content

Not Your Typical CDMO: Comprehensive Cell Solutions

Not Your Typical CDMO: Comprehensive Cell Solutions

byBPI Contributor

10x the mRNA Production with Membrane Chromatography

Sponsored Content

10x the mRNA Production with Membrane Chromatography

10x the mRNA Production with Membrane Chromatography

byBPI Contributor

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