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Quality Testing

Product: Palltronic Flowstar IV instrument

Applications: Filter integrity testing

Features: The Palltronic Flowstar IV integrity test instrument is designed for speed and accuracy in laboratory and cleanroom operations. It offers up to date networking and automation options. Lightweight, ergonomic, and developed in accordance with both GAMP and 21 CFR Part 11, the instrument is supported by detailed qualification documentation and worldwide technical and aftersales support.

Contact Pall Corporation

flowstar@pall.com

www.pall.com

Anion Exchange

Product: Toyopearl Q-600C AR anion-exchange resin

Applications: Protein purification

Features: The Toyopearl Q-600C AR ion-exchange resin is suited for high-capacity capture of biotherapeutics and plasma proteins. The “AR” stands for alkaline resistance. This resin combines high dynamic binding capacity and fast mass transfer kinetics with an improved alkaline stability. It enables both high process throughput and improved process robustness. This ion-exchange capture resin with an average particle size of 100 µm was designed to meet increasing downstream requirements.

Contact Tosoh Bioscience

www.tosohbioscience.com

Virus Filtration

Product: Viresolve Pro+ Solution membrane filtration

Applications: Virus safety in biopharmaceutical production

Features: The Viresolve Pro+ Solution system’s caustic-stable disposable flow path is designed for monoclonal antibody and other protein processes. It provides ≥4 logs parvovirus clearance and <4 hours processing time at scale. A proprietary binary gas integrity test (BGT) is included to detect oversized pores/defects that compromise filter retention capability and cause end-product contamination — providing a quality-control safeguard for end users.

Contact Millipore Corporation

www.millipore.com

Automated Liquid Handling

Product: MVS multichannel verification system

Applications: Performance assessment and optimization for automated liquid handlers

Features: Artel has added features to its MVS multichannel verification system, an objective performance assessment and optimization tool for automated liquid handlers. These features are designed to enhance measurement data comparability, increase the speed of volume verification, and allow users to reduce the overall variability of laboratory processes. The system is compatible with automated liquid handlers from Beckman Coulter, Tecan, Agilent, and Hamilton.

Contact ARTEL

www.artel-usa.com

TFF Process Control

Product: The KrosFlo automatic backpressure valve

Applications: Automated process control of single-use TFF processing systems in bioprocessing

Features: The KrosFlo automatic backpressure valve controls the transmembrane pressure (TMP) or permeate back pressure during tangential flow filtration processes without contacting the fluid stream. It is thus useful for automated process control of single-use TFF processing. When attached to a flexible tubing retentate line, the valve automatically opens and closes to maintain a user-defined TMP. When attached to a permeate line, it opens and closes to maintain a user-defined permeate back pressure.

Contact Spectrum Laboratories

www.spectrumlabs.com

Sample Maintenance

Product: FreezerPro system RFID

Applications: Labeling frozen samples

Features: RURO Inc. introduces a radio-frequency identification (RFID) component for its FreezerPro frozen sample management system. The system creates transparent frozen sample storage with always up-to-date mapping and flexible searching, ensures good sample preservation because samples never leave freezers unless they are used, and facilitates access control management and storage audits. Modern RFID technology is miniaturized and inexpensive. It is applied to storage boxes and cryovials through self-adhesive cryo-safe labels that combine barcode and radio tags for maximum safety and redundancy.

Contact RURO

www.ruro.com

Disposable Dialysis

Product: Tube-a-Lyzer system

Applications: Membrane separations

Features: The Tube-a-Lyzer ready-to-use separation device combines convenience and disposability with the efficiency of dynamic dialysis to increase mass transfer and reduce dialysis times from 1–2 days to 4–12 hours. This self-contained device incorporates semipermeable membrane tubing that separates its sample chamber from the surrounding flow-through buffer chamber. The dry, biotech-grade cellulose ester (CE) membrane tubing comes in six MW cutoffs, and the sample chamber comes in two volume sizes.

Contact Spectrum Laboratories, Inc.

www.spectrumlabs.com

Build Organs Cell by Cell

Product: 3D Bio-Printer system

Applications: Manufacturing human tissue and organs

Features: Organovo will supply Invetech’s world’s-first product-model three-dimensional “bio-printer” to research institutions investigating human tissue repair and organ replacement. These units provide for the first time a flexible technology platform for organizations working on different types of tissue construction and organ replacement. The systems include an intuitive software interface that allows engineers to model of a tissue construct before the printer begins physical construction of the organs cell-by-cell using automated, laser-calibrated print heads.

Contact Invetech www.invetech.com.au.

Contact Organovo www.organovo.com

Online Measurement

Product: #CITSens Bio sensors

Applications: PAT measurement for disposable bioreactors

Features: A #CITSens Bio sensor enables real-time analysis of glucose, glutamate, and lactate by measuring online and in situ directly in a disposable bioreactor. These systems help ensure long-term stability and sterile conditions of a culture while increasing efficiencies in process optimization. They are suitable for three-dimensional cell cultures and development of new cell lines as well as cultures of limited volumes. Each sensor is a screen-printed electrode that can be used with any standard disposable bioreactor.

Contact C-#CIT AG

www.c-cit.ch

Nanoscale Liquid Handling

Product: ProtoCOL 2 system

Applications: Miniaturized assays

Features: Agilent and V&P Scientific provide custom Pintool heads for Agilent Automation Solutions liquid handlers. Pintool heads enable users to convert 96- or 384-well pipetting systems or plate handlers into Pintool workstations that deliver 3 nL to 5 µL using 96-, 384-, or 1,536-pin tools. These heads use the surface tension of pins instead of aspirating through tips to deliver precise nanoliter amounts for multiplexing assays. They transfer 3,000–5,000 nL of liquid to any position on an instrument deck.

Contact Agilent Technologies

www.velocity11.com

Genetic Analysis

Product: IFC Controller MX system

Applications: Drug discovery, cell line development, personalized medicine

Features: The Fluidigm BioMark self-contained system is designed to automatically prime and load 48.48 Dynamic Array and 12.765 Digital Array integrated fluidic circuits (IFCs) one at a time on a BioMark Real-Time PCR system. The compact, fully integrated system has an internal computer, touch-screen control, and internal air source capable of setting up 2,304 reactions within minutes. It is designed for laboratories to undertake high-throughput gene expression, genotyping, and real-time/digital PCR experiments economically.

Contact Fluidigm Europe BV

www.fluidigm.com

O2 Sensors

Product: PnPro6800 oxygen sensors

Application: Inertization of gasses in vaccine production

Features: During vaccine production processes, certain compounds are deteriorated in the presence of oxygen. So measurement and control of dissolved and gaseous oxygen are critical to optimize the gas inertization phase. To help vaccine manufacturers meet that need, Mettler Toledo combines its InPro6800 dissolved- and gaseous-oxygen sensors with its M300 two-channel multiparameter transmitter. The resulting system measures gaseous and dissolved oxygen and features sensor stability and low detection limits.

Contact Mettler Toledo

www.mt.com/Inpro6800

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