Voices of Biotech
Podcast: MilliporeSigma says education vital to creating unbreakable chain for sustainability
MilliporeSigma discusses the importance of people, education, and the benefits of embracing discomfort to bolster sustainability efforts.
Sponsored by LigaTrap
It’s been over 30 years since the identification and commercialization of protein A. Since its inception, protein A has served as the pinnacle purification platform for the immunoglobulin G (IgG) subclass of antibodies, both monoclonal and polyclonal forms. The introduction of protein A paved the way for researchers and large pharmaceutical manufacturers to develop and commercialize IgG-based therapeutics at both small and large scales, provided by its relative ease of use and well-characterized chromatographic attributes. Unfortunately, the gold standard affinity ligand, protein A, does not bind to all immunoglobulin subclasses, including immunoglobulin M (IgM), thereby forcing those working with IgM to find alternative purification strategies and leaving IgM to hitchhike on that “yellow brick road” that protein A offers so readily for IgG.
Moreover, little to no advancements have been made in developing a robust IgM purification platform to date. Therefore, the emergence of IgM-based therapeutics has been hindered. For this reason, it is not surprising that IgM might sometimes be considered “the forgotten immunoglobulin”, relative to its famous immunoglobulin counterpart, IgG. LigaTrap™ Technologies is changing this perception of IgM by bringing to market the first affinity ligands for IgM, offering a new platform for IgM purification, one that can be the missing piece to elevate IgM research and drug discovery to a whole new level.
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