Monday, August 23, 2021 Daily Archives

The Way Forward in Therapeutic Antibody Purification

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This webcast features: Dr. Anna Le Bris, Senior Application Specialist and Trainer, Thermo Fisher The development of therapeutic antibodies has made an enormous progression in the last decades. Antibodies have become the predominant class of biological drugs and are used to treat a variety of diseases such as cancer. Recently, neutralizing antibodies to halt infectious diseases are entering the clinical pipeline, including against Sars-Cov2. Affinity purification platforms such as Protein A or L are well established in the manufacturing process…

Zymeworks on how to keep immune system at bay when developing bispecifics

BioProcess Insider sat down figuratively with Zymeworks’ chief scientific officer Tony Polverino to talk all things antibody and their solution to challenges that surround bispecific antibody-based cancer therapies.   BioProcess Insider (BI): What are the challenges that surround bispecific antibody-based cancer therapies?  Tony Polverino (TP): I think that the challenges fall into a number of different areas, one being manufacturing, as the ability to bring two different molecules together, or two different binding arms together into the same molecule presents a challenge from an expression and a manufacturing perspective. BI: How have you overcome these issues? …

UK group says 3D printed automated control tech can cut mAb production costs

Automation provides a path to cheaper, faster monoclonal antibody (mAb) production says the UK consortium, which is using 3D printing to develop a tech-independent biomanufacturing control system. The consortium – which includes BiologIC Technologies, Biopharm Services, the UK Center for Process Innovation (CPI), Pall and SCIEX – announced the pact in July, explaining the plan is to develop a prototype strategy and overlay it onto an existing, small scale mAb line. BiologIC Technologies’ role is to use its 3D printing technology to develop…