Lipid excipients and delivery systems such as lipid nanoparticles (LNPs) are essential for a wide variety of therapeutics including chemotherapy, analgesics, gene therapy, respiratory and ocular applications, anti-fungal applications, and vaccines. In many cases, these excipients and delivery systems play an important role in achieving the desired bioavailability. mRNA vaccines, for example, require incorporation of lipids to prevent degradation of the nucleic acid and facilitate cellular uptake of the mRNA which is required for antibody generation. The purity and safety…
Thursday, June 9, 2022 Daily Archives
MigVax taps Catalent to deliver COVID-19 vaccine orally
MigVax has teamed with Catalent to develop its subunit COVID-19 vaccine MigVax-101 using the CDMO’s Zydis orally disintegrating tablet (ODT) technology. Israeli crowdfunded biotech MigVax has developed an oral vaccine against COVID-19 that uses a chimeric protein to generate three kinds of simultaneous immunological responses: mucosal, blood-based, and cell-mediated immunity. To overcome delivery issues, the firm has tapped contract development and manufacturing organization (CDMO) Catalent to undertake a feasibility study to formulate MigVax-101 using its Zydis Bio orally disintegrating tablet…