Wednesday, July 13, 2022 Daily Archives

LG Chem licensing electroporation tech from MaxCyte

LG Chem will have non-exclusive clinical and commercial rights to use MaxCyte’s Flow Electroporation technology and ExPERT platform. According to MaxCyte, the partnership will support LG Chem’s CAR-T programs for solid tumors, including LR19023, which is in the pre-clinical stage and being developed as a solid cancer therapeutic. In return, MaxCyte, will receive platform licensing fees and program-related revenue. “This announcement marks our 17th strategic platform license (SPL) partnership,” Doug Doerfler, CEO at MaxCyte told BioProcess Insider. “It represents our…

Improving AAV bioprocess economics for gene therapy

Viral vector manufacturers are looking for ways to leverage existing and new platforms with fit-for-purpose reagents (cell lines, plasmid DNA [pDNA], media, transfection reagent) to identify and optimize critical process parameters across all unit operations. Both upstream steps like transient transfection and the various downstream purification, final formulation, and fill/finish steps have deep impacts on process economics. Double the production, lower the cost To address current limits in rAAV viral vector yields and industrial scalability for suspension cell culture systems,…