Tuesday, August 16, 2022 Daily Archives

Concentration and Purification of Infectious Viruses

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Throughout evolution, viruses have developed mechanisms to interact with and manipulate the genetic material of their target cells. As a result, modern virology uses a growing number of applications to understand these agents of disease. Such applications range from transfection of cells for genetic manipulation to medical studies with a strategic focus on developing novel vaccines, treatments, and gene therapies. Assessment of virus type and content is also important for ensuring food and drinking water safety as well as for…

August 16, 2022

The Changing CDMO Landscape

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Contract development and manufacturing organizations (CDMOs) have evolved from simple service providers to full partners. Such companies now offer development and end-to-end services for highly complex biologics in a transition from contract manufacturing organizations (CMOs) and contract research organizations (CROs) to CDMOs. Before 2000, some drug companies (e.g., Merck, Novarits, Boehringer Ingelheim, and others) offered their excess manufacturing capacity to other drug makers. Chemical companies provided fill–finish and related services. Between 2000 and 2008, a number of dedicated CMOs emerged:…

August 16, 2022

NIIMBL’s Project Call 5.2 looks to address shifting bio-bottlenecks

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The National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) will fund a further 14 projects to address the changing challenges in the biomanufacturing space. Launched in March 2017 as a cooperative agreement with the National Institute for Standards and Technology (NIST), NIIMBL looks to bring industry, academia, and government together to accelerate implementation of advanced biomanufacturing. The Institute’s biannual project calls look to overcome barriers to communication and innovation for biologics technology development, regulatory standards, and workforce development, and the…

August 16, 2022

Tonix looks to live virus vaccines to prevent the spread of monkeypox

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Tonix Pharmaceuticals claims that using a smallpox vaccine model could stop the spread of monkeypox. The technology is being applied to vaccines against COVID-19, smallpox, and monkeypox. According to Seth Lederman, CEO of Tonix, the firm has “recreated a vaccine that we think is similar to what Edward Jenner used” in 1798. While Lederman told us the undisclosed cell line is “pretty standard” in its technique, TNX-801 is a live virus vaccine based on synthesized horsepox (sHPXV) that it claims…

August 16, 2022