Thursday, March 30, 2023 Daily Archives

MAb Purification Process Development Using Mixed-Mode Resins — The DOE Approach

This webcast features: Artur Stanczak, Application Specialist, Process Chromatography, Bio-Rad Laboratories. A monoclonal antibody (MAb) purification process involves multiple consecutive steps, typically using three chromatography resins. These three purification steps are referred to as capture, intermediate, and polish. The workflow is based on multiple criteria to maximize product quality and output, including process efficiencies. One focus area of process intensification is reducing the downstream processing (DSP) steps to improve the MAb purification workflow. Mixed-mode resins are being increasingly integrated into…

Lilly’s $1bn Ireland investment in Limerick… in limericks!

Eli Lilly has doubled its investment into a planned biologics drug substance manufacturing facility in Limerick, Ireland. Having announced plans to build a €400+ million ($433 million) greenfield site in Limerick, Ireland last year, Eli Lilly has magnified the investment to around $1 billion to further support its biologics ambition in the country. The extra investment was announced this week by Ireland’s Industrial Development Agency (IDA), but BioProcess Insider put ChatGPT on the story, but following a confusing prompt or…