With nine products already on the market, bispecific antibodies (bsAbs) are the most commercially advanced of all antibody-derivative biopharmaceuticals. But that isn’t to say that they face no obstacles to success. Indeed, as BPI’s senior technical editor finds in her review of recent literature and conference proceedings, the details of production and processing still confound many bsAb developers. With dozens of molecular formats in progress — and more arising all the time — the prospects for a platform process are…
Thursday, May 25, 2023 Daily Archives
Development of an IEX Purification Process for Lentiviral Vectors
This webcast features: Sushmita Koley, PhD, Senior Scientist, Process Chromatography, Bio-Rad Laboratories. In recent years, gene therapy treatments have increased significantly requiring more efficient processes to purify and deliver these therapeutics. Lentiviral vectors (LVV) are a type of retrovirus and are an effective tool for gene delivery. In this webinar, data will be presented on a high-throughput screening strategy that was employed for LVV purification which provided high yield as well as acceptable HCP clearance. An initial high-throughput screening experiment…
Pfizer expands Epogen biosimilar deal with German CDMO
Norbitec’s biologics facility in Uetersen, Germany will supply Retacrit – Pfizer’s biosimilar of anemia drug Epogen (epoetin alfa) – to the US market. The approval for Retacrit in May 2018 brought the first US challenge to Amgen’s Epogen. Five years on and Pfizer has made a significant dent in the market, with the epoetin alfa biosimilar pulling in $312 million in US sales in 2022. Pfizer’s manufacturing facility in McPherson, Kansas – added through the $17 billion Hospira acquisition in 2015…
ReNAgade takes off with $300m+ to tackle RNA challenges
The $300 million Series A financing round will support development of an all-RNA delivery platform, says ReNAgade. Massachusetts-based start-up company ReNAgade claims its RNA platform combines delivery technologies, such as lipid nanoparticles (LNPs), with a wide range of coding, editing, and gene insertion tools to enable an all-RNA system to develop medicines. With $300 million raised in a Series A financing round led by biotech investors MPM BioImpact and F2 Ventures, a spokesperson for ReNAgade told BioProcess Insider,“the funding will…