Friday, August 25, 2023 Daily Archives

Scalable AAV Vector Purification Workflow Using AEX and Mixed-Mode Chromatography

This webcast features: William H. Rushton, MS, Process Chromatography Scientist, Bio-Rad Laboratories.   Recombinant adeno‐associated viruses (rAAV) are among the most promising vectors for long‐term gene transduction. These viruses have a high degree of safety, making them ideal for gene therapy applications. Significant progress has been made in improving rAAV vector production and purification.   In this study, different chromatography workflow solutions were explored to purify rAAV8. Experimental conditions and data will be presented on using anion exchange (AEX) and…

Fujifilm reveals ‘little and large’ strategies for its CDMO business

In what it describes as a “customer-focused business structure,” CDMO Fujifilm Diosynth Biotechnologies has established separate small- and large-scale biomanufacturing units. The small-scale unit aims to support clients from preclinical all the way through the clinic until commercial production for biologics, cell and gene therapies, oncolytic viruses, and viral vaccines. The unit will leverage Fujifilm’s facilities in Teesside, UK, Triangle Park, North Carolina, College Station, Texas, Watertown, Massachusetts, and Thousand Oaks, California. The Large-Scale unit, meanwhile, will center on Fujifilm’s…

PAT boon! Rentschler, CGT Catapult, Refeyn team on AAV processes

Learnings from a three-way collaboration addressing efficiency of viral vector production will translate into process analytical technologies (PAT) improvements for its customers, says Rentschler. Contract development and manufacturing organization (CDMO) Rentschler Biopharma is combining its expertise with the Cell and Gene Therapy Catapult – a UK-based advanced therapy incubator and collaborator – and analytical instruments firm Refeyn to address difficulties and inefficiencies in the manufacturing of adeno-associated viruses (AAV). The two-year project hopes to develop a digitized and automated manufacturing…

Thermogenesis looks to Cali CGT plant to kickstart CDMO ambition

The Sacramento, California facility, key to Thermogenesis’ CDMO plan, will start welcoming customers by the end of the year. Thermogenesis, a medical device company specialised in base cell banking and cell therapy technology, is getting closer to becoming a full contract development and manufacturing organization (CDMO). “Our priority,” said Chris Xu, CEO, during a Q2 earnings conference call, “is to provide customers with solutions that optimize the supply chain, increasing manufacture, and manage overall risk.” The stepping stone to achieving…

AGC ups cell therapy capacity at Longmont plant

AGC Biologics has added over 30,000 square feet of space to accommodate three cell therapy suites at its Longmont, Colorado site. The latest expansion sees contract development manufacturing organization (CDMO) AGC add two process suites and one flex suite at its Longmont plant, expanding the firm’s cell therapy capabilities. AGC said the additional capacity means the firm can offer its clients a full life cycle of cell therapy advancement and manufacturing services in one location. According to the company, the…