The provenance of eukaryotic CRISPR has not been settled for good by the Patent Trial and Appeal Board. There are four parties involved: CVC, Broad, ToolGen Inc. and Sigma-Aldrich Co.
The application of plant-based expression systems to produce biopharmaceuticals for human and veterinary indications are proving to be safe for clinical use.
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This special report on virus filtration by scientists at Pall Biotech includes discussion of minimizing protein aggregation through formulation and handling considerations.