Author Archives: Dan Stanton

Repligen eyes more M&A and expansions as demand continues to rocket

Repligen says it will both reinvest in its manufacturing network and look for M&A opportunities to feed the high demand for bioprocess consumables. For the full year 2020, bioprocessing tech firm Repligen Corporation reported sales of $366 million, up 36% year-on-year. The fourth quarter itself pulled in $108 million, representing a 56% increase on the same period 2019. As with fellow bioprocess vendors (Danaher, Sartorius, Thermo Fisher etc), COVID-19 played a major part in Repligen’s 2020 top line, with its…

Catalent commits to pDNA, buying Delphi and expanding a Maryland plant

Having its own plasmid DNA capabilities will launch Catalent into areas like mRNA and non-viral gene delivery, the CDMO says. Catalent has entered into an agreement to buy fellow contract development and manufacturing organization (CDMO) Delphi Genetics, adding – if the deal goes through – a plasmid DNA (pDNA) platform and supporting production services from preclinical to Phase III. The deal, financial details of which have not been divulged, will also bring Catalent a 17,000 square-foot facility in Gosselies, Belgium,…

Emergent CDMO biz ‘thriving’ in COVID-19 environment

The COVID-19 pandemic has highlighted the growing mammalian and viral vaccines market and placed Emergent in a “leading position” in the CDMO space, says CEO Bob Kramer. The fourth quarter 2020 produced record revenues for Emergent BioSolutions, with the firm reporting sales of $583 million, up 62% on the year prior. For the full year, sales tallied $1.56 billion, up 41% on 2019. While Emergent has its own product line (contributing $340 million in the quarter, with its smallpox vaccine…

eBook: Vaccines — COVID-19 Invigorates a Stagnant Industry

The SARS-CoV-2 novel coronavirus has galvanized what was a stagnant and oligopoly-run vaccine industry. In this inaugural BioProcess Insider eBook, the first of four to be published in 2021, founding editor Dan Stanton explores economic and technical conditions that until now have hampered innovation in vaccine development and discouraged market entry for emerging biotechnology companies. Leveraging commentary from vaccine industry experts and analyzing the range of emerging vaccine modalities, Stanton surveys how industry responses to the COVID-19 pandemic are fostering…

Charles River to reenter CDMO space in $875m Cognate buy

The proposed acquisition of Cognate BioServices will bring services firm Charles River Laboratories autologous and allogeneic cell therapy, plasmid DNA and viral vector manufacturing capabilities. The agreement announced yesterday will see Charles River pay $875 million in cash for the contract development and manufacturing organization (CDMO). Through the deal, Charles River has propelled itself into the manufacturing space, entering a lucrative cell therapy and plasmid production market. “The addressable market for Cognate’s CDMO services principally cell therapy and plasmid production…

Affinity resins: Avitide gears up to support COVID-19 vaccine makers

Avitide says a specific SARS-CoV-2 virus spike protein affinity resin greatly helps the current COVID-19 efforts and could greatly accelerate the speed of response in future pandemics. Bioprocess service and consumable firms are looking to support the next wave of COVID-19 vaccines as they progress through the clinic. Last week, we reported that Repligen and Navigo launched an affinity resin specifically for the purification of COVID-19 vaccines. But they are not alone, and New Hampshire-based firm Avitide recently finalized its…

Resilience bags Sanofi-Genzyme plant in Boston

Newly formed CDMO Resilience takes over the once-troubled Allston facility in Massachusetts from Sanofi, retaining all 250 staff. Last November, ‘National Resilience’ – less formerly known as Resilience – raised over $800 million in funding and launched itself as a contract development and manufacturing organization (CDMO). At the time, the firm said it will provide “new, better, faster ways” to manufacture cell and gene therapies and alluded to having capacity at multiple facilities to carry out this mission. Now the…

Vigene upping viral vector capacity by 50% through Maryland facility

CDMO Vigene Biosciences has leased a 52,000 square foot facility in Maryland to support ongoing demand for viral vectors. The contract development and manufacturing organization (CDMO) has entered a lease agreement, adding a facility in Rockville, Maryland with supporting infrastructure, including HVAC and flooring and Water for injection (WFI) system in place The additional manufacturing space will complement Vigene’s nearby GMP manufacturing plant, acquired in 2016 through the purchase of assets from Omnia Biologics. The lease brings Vigene’s total lab…

Rentschler catapults into the cell and gene therapy space through UK investment

German CDMO Rentschler will set up manufacturing capabilities at the UK’s Cell and Gene Therapy (CGT) Catapult, launching itself into the regenerative medicine space. Family-owned contract development and manufacturing organization (CDMO) Rentschler offers mammalian manufacturing and fill and finish services for biologics but has now expanded into cell and gene therapy production through a deal with the CGT Catapult, based in Stevenage, UK. Rentschler will establish its manufacturing capabilities – including adeno-associated virus (AAV) vector production – through “a significant…

Podcast: Industry veteran moves to Lykan Bioscience, and this time its personal!

In the latest episode of the BioProcess Insider Expression Platform, we explore the evolution of cell and gene therapy production with new COO of Lykan Bioscience, Patrick Lucy. From Repligen, to Lonza, to Pfenex, Patrick Lucy has had an illustrious career. His latest career move is to Lykan Bioscience, a Massachusetts-based contract Manufacturing Services Organization (MSO) and provider of end-to-end solution for cell-based therapies, where he took on the role of chief operating officer (COO) in January. In this podcast,…