Antimicrobial resistance (AMR) poses a serious public health threat that affects people all around the globe. Although methicillin-resistant Staphylococcus aureus (MRSA) poses a well-understood risk, problems with AMR span beyond that bacteria. Predicting the Impact of Monoclonal Antibodies and Vaccines on Antimicrobial Resistance (PrIMAVeRa) is a program that seeks to help estimate the burden of disease attributable to AMR, which is a complex problem that requires high-quality surveillance data. A recent global study linked 4.95Â million deaths to bacterial AMR in…
Author Archives: Irina Meln
Advancing In Silico Tools for Vaccine Development and Process Modeling
The COVID-19 pandemic has demonstrated the importance of — and significant demand for — vaccines. However, vaccine development for large-scale manufacturing can be difficult and resource intensive because of the diversity and complexity of vaccine types that are needed. Developing a new vaccine typically takes more than a decade, with costs ranging from US$200 million to $500 million per successful program. That figure rises to $8 billion for epidemic vaccines (1). Vaccine programs also face a 90% risk of failure…