Author Archives: Millie Nelson

Biogen and Aduhelm: ‘Manufacturing capabilities will align with demand’

With minimalized demand for the one-time touted blockbuster Aduhelm, Biogen could be left with 198,000 L of mammalian capacity to fill. Between its Swiss site in Solothurn and a plant in North Carolina, Biogen said last year it has a combined capacity of 198,000 L, capable of producing tens of millions of doses of Alzheimer’s drug Aduhelm (aducanumab). However, despite the US Food and Drug Administration (FDA) approving Aduhelm in June 2021, the commercial future of the monoclonal antibody (mAb)…

Maturing gene therapy pipelines driving Catalent growth and expansion

As pharma’s gene therapy pipeline matures, Catalent plans to invest more in the sector to meet high viral vector demand and advance growth. For the third quarter 2022, contract development manufacturing organization (CDMO) Catalent reported total revenues of $1.27 billion, an increase of 21% year-on-year. Catalent’s biologics segment came out as the top contributor to the CDMO’s financial performance, showcasing $698 million, representing net revenue growth of 30%over last year. Part of this success was due to “a notable increase”…

PE firm Astorg to buy CordenPharma from ICIG

Astorg Partners has signed an agreement with International Chemical Investors Group (ICIG) to acquire CDMO CordenPharma. According to French private equity firm Astorg, ICIG chose to sell contract development manufacturing organization (CDMO) CordenPharma after a strategic portfolio review, which concluded its aim to focus more on its chemicals portfolio. Under the terms of the deal, ICIG  will reinvest as partners with Astorg to develop CDMO would further. “We look forward to having the opportunity to partner with ICIG and [CordenPharma’s]…

Quell and Cellistic partner to develop cell therapy platform

The aim of the collaboration is to support the expansion of Quell’s autologous T-regulatory (Treg) cell therapy pipeline using Cellistic’s knowledge of iPSC processes. Under the terms of the deal, Quell Therapeutics and human induced pluripotent stem cell (iPSC) technology development and manufacturing firm Cellistic will take part in joint research to form a process for differentiating iPSCs into functional Treg cell therapy products. According to Quell, it will contribute its Treg expertise and technologies, as well as characterizing Treg…

US Gov awards $10.6m freeze-dried plasma contract to Terumo

Terumo Blood and Cell Technologies has won a $10.6 million contract from the US Government to continue freeze-dried plasma (FDP) development. Apheresis services firm Terumo Blood and Cell Technologies has entered into a contract with the Medical Technology Enterprise Consortium (MTEC), which is an Other Transaction Agreement (OTA) with the US Army Medical Research and Development Command. In 2016, Terumo was awarded initial funding of $1.9 million (potential to be increased to $16 million) from the US Government to support…

Scorpion to build $650m biodefense-focused plant in Kansas

CDMO Scorpion Biological Services has entered a planned development partnership to construct a biodefense and biomanufacturing facility in Manhattan, Kansas. Contract development manufacturing organization (CDMO) Scorpion has announced a development collaboration with a private developer, the state of Kansas, and university affiliates to build a biodefense-focused large molecule and biologics biomanufacturing plant. According to the CDMO, the 500,000 square-foot plant will service around 144,000 L of biomanufacturing capacity across 48 bioreactors, which is being designed for large molecule biologics production.…

Enzyvant to build regenerative med plant in NC to support Rethymic

Enzyvant says the construction of a regenerative medicine facility in Morrisville, North Carolina will bolster its size, flexibility, and capability to support its commercial needs. Financial details of the expansion remain under wraps, but regenerative medicine focused firm Enzyvant says the development of a 25,972 square-foot facility will begin this summer and take around two and a half years to complete. The plant is located within the Research Triangle Park area and is being co-developed by and operated with Sumitomo…

Shingrix sales bounce back post-pandemic for GSK

GSK says its vaccine turnover for this quarter benefited from Shingrix’s post-pandemic recovery in the US and Europe. For the first quarter 2022, GlaxoSmithKline (GSK) reported its vaccine business made a total of ÂŁ1.7 billion ($2.1 billion) in sales. ÂŁ698 million ($866 million) of this was made up of Shingrix sales, the firm’s non-live, recombinant subunit vaccine for the prevention of shingles (herpes zoster). According to GSK, its vaccine business benefited from Shingrix’s “strong demand recovery.” The firm claims it…

Genezen fast tracks second phase expansion in US

Genezen’s aggressive approach has not been aggressive enough says firm as a second phase expansion begins earlier than expected at its lentiviral vector plant.   Gene therapy contract development manufacturing organization (CDMO) Genezen Laboratories has completed construction of a 75,000+ square-foot lentiviral vector production facility in Indianapolis, US and says the next phase of the expansion is underway. The firm said it had allocated space for future expansions but did not expect to be initiating the next phase of the…

NorthX Biologics inks vaccine partnership with Abera

NorthX has signed a partnership agreement to upscale and manufacture Abera Biosciences’ vaccine candidate against pneumococcus, Ab-01.12.   Abera is a vaccine and platform development company, which was founded in 2012 as a spinout from Swedish production firm Xbrane Bioscience. Its lead vaccine candidate Ab-01.12 is administered as a nasal spray and aims to treat pneumococcus using technology designed to protect against all variants of the bacterium. Abera is preparing the vaccine candidate for clinical trials in humans and has…