RNA vaccine manufacturing has lower CAPEX but higher operational costs than AVV vaccine production, says an expert at BPI West. Messenger (mRNA) was thrusted into the limelight through the success of Moderna and BioNTech/Pfizer’s respective COVID-19 vaccines. Their approvals have helped bring confidence to the mRNA sector and drive investment in wider RNA technology platforms. But despite its success, the RNA space still has many challenges to overcome and comparisons to other modalities are heavily debated. Zoltan Kis, lecturer at…
Author Archives: Millie Nelson
Seagen on rumored Pfizer deal: ‘It’s all noise, until it isn’t’
Pfizer is the latest company rumored to be buying antibody-drug conjugate (ADC) developer Seagen, but Seagen says the deal is all noise… until it isn’t. The potential acquisition of Seagen (previously Seattle Genetics) has been circulating news outlets since June last year when the Wall Street Journal reported Merck & Co. was interested in buying the Bothell, Washington to increase its oncology portfolio and pipeline. Last week, the same outlet reported Pfizer is considering purchasing the ADC manufacturer. While the deal is speculative…
Facility buildout does not always begin with bricks, says Genentech
The buildout of a facility ends with technology choices but starts with a purpose, vision, and people, says Roche’s Genentech. Genentech — part of the Roche Group — broke ground on a $450 million expansion at its Oceanside, California site in February 2023; a site it says will work in unison with the recently completed $250 million Clinical Supply Center in South San Francisco (SSF). But when thinking about building a facility, the question “where are we going with the…
eXmoor and Imophoron team to develop vax platform
The collaboration aims to manufacture vaccines for clinical use at eXmoor’s Bristol, UK plant set to launch in Q3, 2023. Cell and gene therapy (CGT) firm eXmoor pharma has partnered with vaccine platform developer, Imophoron. The first step of the agreement will see eXmoor develop a scalable manufacturing platform for Imophoron’s vaccine technology. Under the terms of the agreement, the platform will initially be optimized for Imophoron’s Respiratory Syncytial Virus (RSV) targeted vaccine. After this, a technology transfer of the…
Resilience MA plant slowdown after Sanofi contract ends
Resilience has reduced operations at a former Sanofi plant in Massachusetts, following the ending of its contract to manufacture enzyme replacement therapy, Cerezyme. Contract development manufacturing organization (CDMO) National Resilience has said it is reducing operations at its 310,000 square-foot plant in Allston, Massachusetts, which it acquired from Sanofi in February 2021. Sanofi itself added the facility through the $20.1 billion acquisition of Genzyme in 2011. The decision to reduce operations at the facility comes after the contract to manufacture…
Agilent breaks ground on $725m site in Colorado
Agilent Technologies has started construction to double manufacturing capacity of therapeutic nucleic acids in Frederick, Colorado. According to the research, development, and manufacturing firm, the facility will create over 160 life sciences jobs in the Frederick location. Additionally, the investment will bolster US production for active pharmaceutical ingredients (APIs) that are used to treat a wide range of illnesses, such as cancer, infectious diseases, and cardiovascular diseases. “Agilent has had a growing presence in Colorado for more than 20 years.…
Donaldson buys reagent firm Isolere Bio
The acquisition of Isolere aims to position Donaldson to form separation and filtration solutions for emerging genetic-based drugs, says firm. Minneapolis-based filtration firm, Donaldson Company, has bought early-stage biotech firm, Isolere, for an undisclosed fee. Isolere develops IsoTag reagents, which it says have been designed to drastically increase product quality and purity with quicker timelines to advance and enable access to affordable therapies. “With the integral addition of Isolere to our Life Sciences portfolio, Donaldson is positioned to create premier…
Myeloid to run $96m Australian RNA facility
Myeloid Therapeutics has been selected to operate an RNA research and pilot manufacturing plant at Macquarie University in Sydney, Australia. The facility, which will be located at Macquarie University’s Wallumattagal campus, has been called the “first-of-its-kind” in Australia by the New South Wales (NSW) government. The partnership between Myeloid and the NSW Government aims to support the State’s ability to develop and produce RNA-based therapeutics and vaccines locally. “The cutting-edge work that will be done at this world-leading facility has…
Oxford Properties Group acquires Resilience site for $125m
Oxford will acquire National Resilience’s manufacturing facility in Marlborough, Massachusetts and then lease the property back to the CDMO. Global real estate investor Oxford Properties Group (Oxford) says the purchase and lease back of the 120,000 square-foot biomanufacturing facility from and to contract development manufacturing organization (CDMO) Resilience will expand its North American footprint while raising proceeds for the CDMO. “This is a financing transaction that has no impact to operations. Resilience has sold the real estate of the site…
Maxion to develop antibody platform with $16m funding
Maxion Therapeutics’ $16 million Series A financing round will be used to develop biologics targeting ion channels and GPCRs via its KnotBody platform. Cambridge, UK based firm Maxion said ion channels and G-protein-coupled receptors (GPCRs) are essential cell surface proteins, which can be used to treat a range of diseases, including chronic pain and autoimmune conditions. The Series A funding round, led by LifeArc Ventures, BGF, and Monograph Capital, will support the advancement of Maxion’s KnotBody platform. To date, small…