Author Archives: Millie Nelson

Vector BioMed launches CDMO following $15m funding

The CDMO says the funding will support delivery of rapid access to lentiviral vectors for pre-clinical development, clinical trials, and commercialization. Vector BioMed, a contract development manufacturing and organization (CDMO) focusing on the production of lentiviral vectors, has launched after its first financing round. “The first tranche was $7.5 million of $15 million,” a spokesperson for the start-up told BioProcess Insider. The funding aims to take the company’s vector-based medicinal concepts from the clinic and accelerate them towards commercialization. To…

BioNTech completes $43m pDNA facility in Germany

BioNTech says the completion of its first inhouse plasmid DNA (pDNA) facility in Marburg, Germany aims to increase manufacturing flexibility and support its oncology and COVID-19 pipeline. pDNA acts as an important starting material for the production of messenger RNA (mRNA) based therapeutic and vaccines, including cell therapies. The recently completed facility – which was acquired from Novartis in September 2020 – will enable BioNTech to independently manufacture pDNA for various clinical product candidates, as well as commercial products for…

Bionova to quadruple Fremont plant biologics capacity

Bionova Scientific has commissioned a third CDMO facility in Fremont, California, freeing space to quadruple manufacturing capacity at its nearby plant. Bionova, which fully transitioned into a contract development and manufacturing organization (CDMO) in November 2021, and was later acquired by Asahi Kasei Medical in April 2022, is set to begin the first phase of its strategic expansion. The firm already operates from two facilities in Fremont. One of the plants acts as its headquarters and the other is a development…

EVEON and Sensorion to advance delivery of ear gene therapies

The firms will work collaboratively to develop an injection system for the delivery of Sensorion’s gene therapy products for the inner ear. EVEON, a company that designs and builds custom devices for preparation and administration of advanced therapeutic treatments, has partnered with Sensorion, a biotech firm that focuses on the development of therapies to treat, prevent, and restore hearing loss disorders. Together, they aim to design and advance an injection system to deliver Sensorion’s gene therapies to the inner ear,…

Andelyn to manufacture vision loss gene therapy for Odylia

Andelyn Biosciences will produce Odylia Therapeutics’ gene therapy, OT-004, which aims to treat vision loss caused by the RPGRIP1 gene. Contract development manufacturing organization (CDMO) Andelyn has partnered with nonprofit biotech firm Odylia to produce OT-004, which is an investigational adeno-associated virus (AAV) that uses the ancestral AAV, Anc80 to create an efficient gene transfer of RPGRIP1 to treat vision loss in individuals that lack a functional copy of the gene. “Andelyn’s adherent production platforms utilize a transient transfection of…

Sanofi to cut hundreds of jobs at two India vaccine plants

Sanofi plans to let go of all its employees at its manufacturing facilities near Hyderbad, following an operations review. According to Reuters, the decision for French drug maker Sanofi to let go of all employees at its two Indian vaccine plants follows the firm’s failure to win a UNICEF contract. The article outlined around 800 members of staff could be affected by the decision and said the Sanofi sources are not being named due to confidentiality. “Over the last few…

Catalent addressing CGT challenges with supply chain service

Catalent has designed a case management service, which aims to tackle challenges associated with the safety and timeline of cell and gene therapy programs. Contract development manufacturing organization (CDMO) Catalent says the complex nature associated with delivering doses of cell and gene therapies (CGTs) means the products need to be managed correctly and efficiently to reduce the risk of production schedule disruption and administration of the therapy to the individual. The launch of the company’s case management service looks to…

Kaneka injects $15m to expand mRNA capacity in Belgium

Kaneka Eurogentec says the investment will create a production capacity approximately five times higher than at its plant in Liège, Belgium. Contract development manufacturing organization (CDMO) Kaneka Eurogentec, an affiliate of Kaneka Corporation, provides offerings including plasmid DNA (pDNA), recombinant proteins, and oligonucleotide services. In 2020, the company started production services for messenger RNA (mRNA) and the $15 million investment aims to scale-up capacity and expand its CDMO business with operations expected to begin from the end of this year. According…

MD Anderson touts ‘entirely new modality for delivering mRNA’

Researchers led by the University of Texas MD Anderson Cancer Center have developed a delivery system for mRNA using extracellular vesicles (EVs). The study, published in Nature Biomedical Engineering, details how the researchers used EV-encapsulated messenger RNA (mRNA) to produce collagen for numerous months in the cells of photoaged skin. The researchers claim this is the first therapy that represents a proof-of concept for using EV mRNA therapies. EVs are small structures formed by cells that transport biomolecules and nucleic…

Lonza experiences CGT headwinds but hails pipeline for bounce back

Lonza says a slowdown in funding and clinical trial issues in 2022 led to slower cell and gene therapy (CGT) sales growth compared to 2021. Contract development manufacturing organization (CDMO) Lonza reported sales of 6.2 billion CHF ($6.7 billion) in Q4 2022, a 15.1% sales increase on 2021. Its biologics division sales grew by 21.7% compared to 2021 and the firm’s CGT business sales increased by 13.6%. Lonza’s chief financial officer (CFO) Philippe Deecke attributed the smaller sales growth of…