Author Archives: Sartorius

Application Note: Early-Stage Process Optimization for Seamless Scaling of MSC Therapies

A single dose of MSC therapy could consist of billions of cells per patient. To sustainably meet this clinical demand, cell expansion processes must be transformed from static cultures to suspension-based systems. This application note describes an efficient approach to process optimization in a scale-down model for suspension-based cell expansion. Read more to learn how to: • Comprehensively screen media and components for optimal cell growth • Rapidly characterize phenotypic and functional CQAs of MSCs • Develop process knowledge early…

Realizing the Potential of Immune Cell Therapies

Remarkable progress is being made in the treatment of cancer. Among the most promising approaches is immune cell therapy, the most prominent type of which is CAR-T therapy. CAR-T therapies have been approved since 2017 and hundreds of clinical trials are now underway. While the race to develop these complex therapies continues to pick up speed, strategies to reduce the steep costs associated with their manufacturing are evolving at a rapid pace. In this article, we outline the factors contributing…