Tosoh Bioscience LLC, a provider of chromatographic resins for the purification of biopharmaceutical drugs in commercial manufacturing processes, today announced the introduction of TOYOPEARL AF-rProtein L-650F, a Protein L resin that exhibits the highest binding capacity for antibody fragments that lack a Fc-portion (e.g. Fab, ScF Dab, etc.). TOYOPEARL AF-rProtein L-650F resin is now available for sale in the Americas from Tosoh Bioscience LLC.
TOYOPEARL AF-rProtein L-650F resin does not only offer the highest binding capacity, but also has the ability to bind to antibody classes that do not have the affinity to Protein A, such as IgM and IgA.
The selected recombinant protein L ligand used in the TOYOPEARL AF-rProtein L-650F resin is alkalistable and therefore able to withstand the high alkaline conditions necessary for clean-in-place (CIP). This resin exhibits stability in various solutions and over a wide pH range, as well as demonstrates excellent pressure-flow rate properties.
“We are excited to introduce yet another innovative addition to our versatile process media product line,” said Phu Duong, PhD, Product Manager II, Process Media at Tosoh Bioscience LLC. “Because of the higher dynamic binding capacity of the TOYOPEARL AF-rProtein L-650F resin, our customers will find that this resin provides improved process economics and will therefore experience higher yield.”