JSR Corporation has teamed with PeptiDream to develop a synthetic peptide-based affinity chromatography media that could be an alternative to costly Protein A resin.
The partnership will combine PeptiDream‚Äôs drug discovery platform, PDPS (Peptide Discovery Platform System), with JSR‚Äôs knowledge of affinity separation technology to develop affinity chromatography media from unique peptides that bind to various target proteins in a specific manner.
A peptide-based resin can be a platform for affinity purification for various types of therapeutic proteins, it could also serve as a cost-effective alternative to Protein A in the production of monoclonal antibodies (MAbs), Masayoshi Nagaya, senior global technology manager at JSR LifeSciences told this publication.
‚ÄúIn today‚Äôs modern therapeutic antibody production, Protein A is used in most manufacturing processes because of its ease of use, shorter development times as well as it‚Äôs robustness and effectiveness in purifying,‚ÄĚ Nagaya said. ‚ÄúUse of protein A enables higher than >95% purity of bulk drug substance with this one chromatography step.‚ÄĚ
But while Protein A is deemed to be the gold standard for MAb capture in large-scale purification, because the ligands are made from biological processes, protein A prices accounts for a¬†large portion of the overall raw material costs¬†in the overall production. Therefore, finding an alternative could bring down the COGS for MAbs.
Step in peptides, and according to Nagaya such products can be designed to have specificity enabling recognition and binding to certain protein surfaces. ‚ÄúWe can use that property to be applied for separation and recovery of target proteins.‚ÄĚ
As peptides are synthesized in a chemical process, the cost will be significantly lower. ‚ÄúThis cost comparison can be made for drug prices today; small molecule drugs vs. large molecule (biological) drugs.‚ÄĚ
The length of the project between the two Japanese firms is to be determined, and financial details have not been divulged.