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BioProcess International

Covering the whole development process for the global biotechnology industry

  • Upstream
    Processing
    Bioprocessing begins upstream, most often with culturing of animal or microbial cells in a range of vessel types (such as bags or stirred tanks) using different controlled feeding, aerating, and process strategies.
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    Beginning with harvest of material from a bioreactor, downstream processing removes or reduces contaminants to acceptable levels through several steps that typically include centrifugation, filtration, and/or chromatographic technologies.
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    Drug products combine active pharmaceutical ingredients with excipients in a final formulation for delivery to patients in liquid or lyophilized (freeze-dried) packaged forms — with the latter requiring reconstitution in the clinical setting.
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    Many technologies are used to characterize biological products, manufacturing processes, and raw materials. The number of options and applications is growing every day — with quality by design (QbD) giving impetus to this expansion.
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    Even as it matures, the biopharmaceutical industry is still a highly entrepreneurial one. Partnerships of many kinds — from outsourcing to licensing agreements to consultancies — help companies navigate this increasingly global business environment.
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Upstream Development

Assays for Controlling Host-Cell Impurities in Biopharmaceuticals

by BPI Contributor
February 1, 2005

Microbial Process Development for BioPharmaceuticals

by BPI Contributor
June 1, 2004

How the Data Ecosystem Affects Process Development and the Bottom Line

by BPI Contributor
May 1, 2004

Getting the Most from Your Biotech Facility

by BPI Contributor
May 1, 2004

Chapter 3: Applying the Technology

by BPI Contributor
April 1, 2004

Manufacturing Capacity Put on Simmer

by BPI Contributor
February 1, 2004

A Design Approach to Biotech Process Simulations

by BPI Contributor
October 1, 2003

Development Partnerships

by BPI Contributor
August 1, 2003

From Discovery to the Clinic

by BPI Contributor
May 1, 2003

Glycosylation Variations with Expression Systems

by BPI Contributor
April 1, 2003
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Editor’s Choice

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    Keeping supply chains resilient in times of crisis

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  • Sponsored Content

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    CAR-T approvals marred by autologous manufacturing limitations, says Allogene

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  • Sponsored Content

    Ask the Expert: Analytical Tools to Accelerate Cell-Line Development Workflows

BioProcess Insider News and Analysis

Recent Tweets

  • Tweet Avatar RT @Dan5tanton: Two co-founders of Taiwanese firm JHL Biotech were sentenced last month for plotting to steal trade secrets from Ge… https://t.co/0iclK4yS7h 2 months ago
  • Tweet Avatar RT @frankvinluan: Shutdown comes 8 months after FDA sent a warning letter about a #microbiome metabolic therapy the #biotech was test… https://t.co/FgtTS54Yj0 2 months ago
  • Tweet Avatar RT @Dan5tanton: A win for CDMO Catalent as it further strengthens its global network, but potentially a loss to the UK taxpayer, wh… https://t.co/Ex9CNdbcf0 2 months ago
  • Tweet Avatar RT @Dan5tanton: The US Department of Health and Human Services #HHS has terminated a long-term #CDMO partnership with Emergent BioS… https://t.co/bAbKWb3uqQ 7 months ago
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