Upstream & Downstream Processing

HPNE to expand single-use capacity on back of $15m BARDA contract

Funding from BARDA gives High Purity New England (HPNE) the opportunity to expand into its fourth facility, the bioprocess vendor says. HPNE has been contracted to produce pharmaceutical consumable equipment for the Biomedical Advanced Research and Development Authority (BARDA) and its third parties, issued in response to a Presidential Declaration of Public Health Emergency. The $15 million contract – number 75A50122C00009 – forms part of the office of the Assistant Secretary for Preparedness and Response at the US Department of…

Danaher: $10bn+ war chest in 2022 but sees no gaps in bioprocessing

Danaher Corporation claims to be the leading player in bioprocessing and hopes to strengthen the offering further in 2022 through opportunist acquisitions. In 2021, Danaher Corporation spent over $10 billion in M&A deals. The bulk of the capital – $9.6 billion – was used to enter the contract development and manufacturing organization (CDMO) through the addition of Aldevron, though other deals in the life sciences space included the addition of lipid nanoparticle tech firm Precision Nanosystems (PNI). And discussing the…

Thermo Fisher buys recombinant protein maker PeproTech for $1.85bn

Thermo Fisher has opened its M&A war chest early in 2022, buying biopharma reagent firm PeproTech for $1.85 billion. The deal, announced on December 30, closed yesterday, adding Cranbury, New Jersey-based reagent maker PeproTech to Thermo Fisher Scientific’s cell culture media offering. Founded in 1988, PeproTech offers over 2,000 cytokines, antibodies, ELISA, and cell culture media kits for the development and manufacturing of biologics and cell and gene therapies. According to Thermo Fisher’s CEO Marc Casper, the acquisition “will be…

Bioanalytics booster: Sartorius takes stake in Automated Lab Solutions

Sartorius has acquired 62.5% of cell isolation firm Automated Lab Solutions (ALS) with the remaining shares set to be purchased in 2026. Jena, Germany headquartered ALS is the latest investment in bioanalytics by life sciences firm Sartorius. The deal, announced late last year, adds solutions for the automated analysis, selection and isolation of cells to Sartorius’ offerings, and adds around 30 people to its staff. Gerry Mackay, member of the Executive Board and Head of the Lab Products & Services…

Digital transformation must be driven by technology and savvy staff

Staff who understand the benefits of digital manufacturing are as important as the technology itself, according to a Novartis expert Digitization is a hot topic for biopharma. Advocates say the ability to monitor and model manufacturing data in real-time as a major advantage in terms of product quality and consistency. Technology is driving the shift from analog. But having staff who understand the benefits is as important according to Francisca Gouveia, a Senior Process Expert, MS&T at Novartis, who says…

Danaher and COVID: $2bn orders for 2022 without potential Omicron windfall

COVID-19 continues to drive bioprocess orders for Danaher Corporation, but the extended vaccine rollout and the unknown impact of the Omicron variant could see a further surge in 2022. In April, Danaher spoke about its efforts in the manufacture of COVID-19 vaccines and therapeutics, adding an estimated $2 billion in 2021 revenue to its bioprocess businesses Cytiva and Pall. As 2022 appears over the horizon, CEO Rainer Blair told delegates at the Evercore ISI Annual HealthCONx Conference orders for COVID-related…

Scaling-up AAV production? Take your time to develop best processes

The lack of standardization surrounding gene therapy production means process design can be more important than speed to clinic, says Oxford BioMedica’s CCO. The complexities of manufacturing monoclonal antibodies (mAbs) has been ironed out somewhat over the 30+ years of their presence commercially. But for the burgeoning gene therapy sector, there are no standardized mammalian-based platforms, for example, nor tried-and-tested upstream and downstream processes. “Viruses and viral vectors come in many shapes and sizes, each with their own characteristics,” Dave…

Generate Biomedicines raises $370m to advance AI drug discovery tech

Generate Biomedicines has raised $370 million to further develop its artificial intelligence (AI) drug discovery technology, expand its team and build labs. The Cambridge, Massachusetts biotech completed a series B round last week, attracting investment from founding backer Flagship Pioneering and the Abu Dhabi Investment Authority (ADIA), the Alaska Permanent Fund and Altitude Life Science Ventures. Generate said the money will allow it to “advance and evolve” the platform and “scale the organization with top-tier scientific and computational talent.” It…

Thermo Fisher and 3M team on chromatography tech

Leveraging Thermo Fisher’s single-use bioreactors systems with 3M’s purification platform aims to improve harvesting and clarification of monoclonal antibodies, the firms say. The collaboration – financials of which have not been divulged – allows Thermo Fisher to serve as an authorized reseller of 3M’s single-stage purification technology Harvest RC Chromatographic Clarifier with its own HyPerforma single-use bioreactor systems up to the 5,000 L scale. 3M’s tech is used to separate recombinant proteins, in particular monoclonal antibodies (mAbs) and according to…

Ins and outs: Avid create viral vector position to lead CGT expansion

CDMO Avid Bioservices has appointed Elie Hanania as vice president, process development, viral vector technologies to lead the company’s efforts in the CGT space. Sit back, relax, and enjoy this week’s Ins and outs. Biologics contract development and manufacturing organization (CDMO) Avid Bioservices turned to the production of viral vectors in October with plans to build a 53,000 square foot viral vector development and GMP manufacturing facility in Costa Mesa, California at a cost of around $75 million. Now, with…