Upstream & Downstream Processing

COVID-19 vaccine: A $14bn opportunity for bioprocess vendors

The big four bioprocess vendors – Thermo Fisher, Danaher, MilliporeSigma, and Sartorius – are set to benefit from the commercial success of COVID-19 vaccines, according to Evercore ISI. There are a host of vaccine candidates targeting the novel coronavirus (SARS-CoV-2) moving into and through the clinic, and while there is no guarantee of success a breakthrough product will be a lucrative market opportunity. Specifically, a commercialized product could be worth upwards of $100 billion (€89 billion), according to the team…

Cytiva shares tips for viral vector production

The viral vector market is highly active, and the interest in production technologies is driven by recent approvals in cell and gene therapy, says Åsa Hagner-McWhirter, senior scientist at Cytiva. Demand for viral vector production is high. The main driver is the large pipeline in different clinical stages and scales. In 2018 there were 724 clinical trials for gene therapies and gene-modified cell therapies, many of which use viral vectors. Adenoviruses and retroviruses, including lentivirus, are frequently used. Adeno-associated virus…

Prefab facilities could feed the need for COVID vaccine capacity, say Univercells and Exyte

Exyte and Univercells Technologies have teamed to develop and construct modular GMP vaccine manufacturing plants that can be deployed in a third of the time of conventional facilities. As vaccines against COVID-19, caused by the SARS-CoV-2 virus, begin to move through the clinic at an unprecedented speed, the question is rising as to how industry can scale-up production. At the heart of this is ensuring capacity is available to produce millions, if not billions, of doses of a potential vaccine.…

Cytiva to help Takara gear up for COVID-19 vaccine production

Cytiva will help Japan’s Takara Bio prepare manufacturing processes for a DNA-based SARS-CoV-2 vaccine candidate. Cytiva announced the collaboration this week, explaining it will work with Takara and partners Osaka University and AnGes to develop production processes and technology for the vaccine. Stephane Perrey, general manager for Cytiva in Japan, Australia, and New Zealand, told us “Cytiva is providing process design consultation, prioritization of equipment manufacturing and prioritization of consumables manufacturing. “We worked closely with Takara Bio to help them…

Rapid Micro Biosystems to fund EU facility construction with $120m fundraising

US sterility testing tech firm Rapid Micro Biosystems will build a European plant and expand its business with $120 million raised this week. The Lowell, Massachusetts firm – which makes automated microbial detection systems – completed a $120 million financing round this week, attracting equity investment from The Ally Bridge Group, Endeavour Vision, and existing investors including Asahi Kasei. CEO Robert Spignesi told Bioprocess Insider the firm’s “growth plan includes establishing new manufacturing capacity, beyond our current US manufacturing facility…

MilliporeSigma reports robust Q1 on back of COVID-19

Merck’s MilliporeSigma is the latest to report bioprocess resilience in the face of COVID-19, and like others has even seen an increase in sales and projects. MilliporeSigma, the life sciences division of Germany’s Merck, saw sales of €1.8 billion ($2 billion) in the first quarter of 2020, up 6.5% on the same period last year, fueled in part by its Process Solutions business unit, which saw sales grow organically by 13.2% (another example of double-digit growth in the biopharma equipment…

Greenlight raises $17m for mRNA vaccine capacity hike citing COVID-19 target

GreenLight Biosciences says a manufacturing expansion will allow it to make billions of doses of its mRNA-based COVID-19 vaccine. The Boston biotech announced the expansion plan last week, explaining it will use $17 million raised in a recent funding round to build out its scalable mRNA production capability. GreenLight is developing several mRNA vaccine candidates against SARS-CoV2, the virus responsible for COVID-19 disease. The aim is to establish “a scaled process under current good manufacturing practices (cGMP), capable of supporting…

Charles River: COVID forces closure of donor clinic disrupting HemaCare biz

Charles River says its cell therapy services business HemaCare is susceptible to the impact of COVID-19 and has already had to temporarily close its donor collections clinic. Charles River Laboratories acquired HemaCare for $380 million in December last year, bolstering its cell therapy services business. HemaCare provides human primary cells as well as services used in the discovery, development and commercial production of cell therapies, and provides leukapheresis services for materials used in the manufacture of Novartis’ Kymriah (tisagenlecleucel), Kite’s…

Univercells on balancing its bioprocess tech and CDMO subsidiaries

Univercells has launched a bioprocess technology subsidiary it says can offer a new generation of biomanufacturing platforms that can solve industry’s manufacturing challenges. It has been a busy few months for Belgium-based biologics platform firm Univercells. In February, global investment firm KKR – through its portfolio of life sciences tools companies Gamma Biosciences – committed €50 million ($54 million) into the firm Univercells. Then last month, the firm launched Exothera, a process development and viral vector contract development and manufacturing…

Fujifilm licenses AAV vector tech to speed gene therapy production

CDMO Fujifilm Diosynth Biotechnologies (FDB) says partnering with OXGENE could reduce the lead time of its customers’ gene therapy projects by up to 25%. The technology, licensed from UK-based OXGENE for an undisclosed fee, consists of Helper, Rep/Cap and Gene of Interest plasmids, used in combination with a clonal suspension a HEK293 cell line. The AAV system is expected to reduce the length of the supply chain gene therapy customers, according to contract development and manufacturing organization (CDMO) FDB, with…