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Protein Capture Innovation from WL Gore & Associates

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This interview features: William Barrett, PhD, Product Specialist, WL Gore & Associates. William Barrett, PhD is a product specialist with WL Gore & Associates. He has over 20 years combined experience in biotechnology, chromatography, and the medical device industries. Most recently at WL Gore, Bill’s focused on affinity purification chromatography. Previously, Bill worked at Agilent on affinity depletion devices used in biomarker discovery and proteomics. He received a PhD in biochemistry from the University of Illinois and completed his fellowship…

March 22, 2023

Product Safety Testing

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This interview features: Amy Bennett, Manager of Virology Scientific Support, Charles River Laboratories. Amy joined Charles River in 2010 as technician within the Virology Department and is now manager of Virology Scientific Support. She currently oversees development within the department as well as technical transfers. Amy has worked on the development and implementation of safety assays for various gene therapy vectors including adenovirus, adeno-associated virus, and lentivirus. She has a master’s degree in biology from West Chester University.

March 22, 2023

Leap-In to the Future of Cell Line Development

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This interview features: Claes Gustafsson, Co-Founder and CCO, ATUM. Launched only a few years ago, the Leap-In Transposase platform has rapidly become an industry standard technology for the generation of CHO cells for the manufacturing of antibodies and other biologics. This presentation will highlight achievements and case studies of the platform including high titer MAb manufacturing, rapid anti-COVID responses, and some novel, next generation, applications.   Speaker Bio: As ATUM’s Co-Founder and CCO, Dr. Claes Gustafsson oversees most of the…

March 21, 2023

Process Intensification and Continuous Bioprocessing for MAbs

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This interview features: Mark Schofield, PhD, Senior R&D Manager, Pall Biotech. Schofield was interviewed at BPI West 2023 by Informa Connect Life Sciences Producer, Anna Brown about his talk on process intensification of monoclonal antibodies. Description: Streamlined process intensification of MAb production can provide a reduction in cost and increase accessibility. Here, a multifaceted approach is taken to address the process intensification of a biosimilar. Design of Experiments (DoEs) spanning sequential unit operations focused on the interconnectivity of the process,…

March 21, 2023

Critical Factors of Fill Finish Manufacturing for Large Molecules

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With the explosion of the large molecule (biologics) market, the industry has entered a new era of drug development. This growth — 10% to 15% each year — is being driven by monoclonal antibodies (mAbs), which are anticipated to have worldwide sales of over $240 billion by 2025. However, with this expanding market comes some considerable challenges for drug manufacturers due to the fragile nature and instability of these large, complex molecules. As compared to small molecules, large molecules generally…

March 20, 2023

Advantages of Mixed-Mode Chromatography in Host Cell Protein Removal

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This webcast features: Thomas Valorose, Senior Product Manager, Astrea Bioseparations. Despite considerable advances in downstream purification for MAbs and other recombinant proteins from various expression systems, there remains a need for effective removal of process and product related impurities that could impact product safety, stability, and efficacy. Many workflows today utilize multiple steps to polish their product, including ion exchange and hydrophobic interactions. Utilizing mixed-mode purification techniques, Astrea Bioseparations delivers a solution that has several advantages over traditional workflows. By…

March 17, 2023

Accelerating Antibody Characterization and AAV Analytics Using Next Gen Biolayer Interferometry (BLI)

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This webcast features: Benjamin Osborne, PhD, Senior Application Scientist, Gator Bio. Efficient kinetics and epitope binning studies are critical to biotherapeutics development. Biolayer Interferometry (BLI) is an exceptional tool to easily and quickly obtain results. In the face of modern throughput challenges, BLI instruments were historically modified to monitor multiple wells per spectrometer, resulting in poor kinetics measurements. To address these shortcomings, Gator Bio has launched the Gator Pro that enables 32 high frequency parallel measurements, alongside a family of…

March 10, 2023

Responding to a Changing Drug Product Global Supply Chain

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Of the many lessons learned during the pandemic, one overriding realization was that utilization of the primary, single-location manufacturing site, although the simplest and potentially most cost-effective strategy, can have significant consequences to the availability of critical life-saving biologics and vaccines. This scenario not only applies to drug product but also to drug substance and the wide range of raw materials used throughout the manufacturing supply chain. Thus, the need for ongoing production from multiple drug substance (DS) and drug…

March 7, 2023

Unbiased nature of TEM ideal complement to in-vitro assays

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Transmission Electron Microscopy (TEM) is the ideal complement to in-vitro assays and molecular techniques in determining the microbiological safety of biological products. TEM is a powerful tool in the biopharmaceutical industry, allowing for high resolution imaging of microscopic structures at the nanometer scale. This technique utilizes a beam of electrons that passes through a thin section of a specimen, producing detailed images of the internal structure of the sample. With the ability to magnify samples up to one million times…

March 3, 2023