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Application of an Effective In-Line Analytical Instrument for Biopharmaceutical Development and Manufacture

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The rapid advancement and competitiveenvironment of the modern biopharmaceutical industry, accompanied by the need for continuous quality improvement, demand robust analytical instruments. Analytical technology is one key factor contributing to the quality and safety of finished products. Ongoing improvements in analytical instruments are needed to address new challenges, including specificity of target substances, high complexity of matrices, and multiple production stages with a number of input and output parameters and peculiarities. Those factors point to the demand for a versatile…

March 2, 2023

Beyond Standard Protein A Resin: Establishment of an Improved DSP Affinity Platform Step for Monoclonal Antibodies

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This webcast features: Manuel Matos, PhD, Field Application Scientist, Thermo Fisher Scientific and Marco Baldazzi, DSP Research Laboratory Technician, Menarini Biotech. While protein A affinity chromatography is the most commonly used method for monoclonal antibody (MAb) capture in clarified harvest coming from CHO cell cultivation, one significant challenge is the high cost of the media required when using these resins. Therefore, it’s crucial to evaluate alternative strategies that may reduce costs and increase productivity without affecting product quality attributes. In…

March 1, 2023

Enabling Faster Feed Strategy Optimization with Rapid Spent Media Analysis and Data Visualization Tools

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This webcast features: Milla Neffling, PhD, Bioprocessing Market Segment Manager, 908 Devices. Optimization of feed strategy to boost process productivity and meet critical quality attributes can greatly benefit from using real-time analytics to gain key insights into the process. Frequent measurements of key nutrients and metabolites in spent media also come with the challenge of generating daunting amounts of data. Bioprocess data visualization can therefore be a cumbersome and lengthy task when multiple dynamic key factors are considered. We highlight…

February 24, 2023

Production and Purification of Newcastle Disease Virus: A High-Yield Platform Process Based on a Novel Avian Cell Line and Monolith Chromatography

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Newcastle disease is an extremely infectious condition among domesticated poultry and other avian species. Its high morbidity and mortality rates among infected birds give the disease significant economic importance. Thus, many commercially available vaccines based on live or inactivated virions are used globally to protect against Newcastle disease infection. The causative agent is Newcastle disease virus (NDV), which belongs to the Paramyxoviridae family. NDV is a single-stranded, negative-sense, enveloped RNA virus of avian origin that is highly attenuated in humans…

February 9, 2023

Save Valuable Facility Time with Single-Use TFF

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Biopharmaceutical developers and manufacturers are part of a global, dynamic, and highly competitive market. They face constant pressure to produce high-quality products within relatively short time frames and at reduced costs. Process-intensification strategies and single-use (SU) solutions are popular approaches to maximizing productivity and promoting fast, efficient, and lean processing — the pillars of next-generation facilities. Filtration is an integral part of all bioprocesses and is applied to many up- and downstream steps, including harvest, clarification, and concentration/diafiltration. Tangential-flow filtration…

February 9, 2023

Less Is More in mRNA Therapeutics: Developing Big Ideas at Small Scales

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In a November 2022 webinar, Linda Mathiasson (strategic customer lead at Cytiva) discussed the significant promise of messenger ribonucleic acid (mRNA), its role in fighting genetic and infectious diseases, and how its production can be scaled to meet the needs of different applications, ranging from large-scale vaccination to production of individual therapies. The Presentation Thanks to the rapid development of mRNA vaccines for COVID-19, the biopharmaceutical industry has gained momentum toward realizing the technology’s potential. The speed, flexibility, and low-cost…

February 9, 2023

Grow Your CDMO with Automated Aseptic-Filling Workcells

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Contract development and manufacturing organizations (CDMOs) and biopharmaceutical companies are facing shortages in capacity for production of clinical trial material. Even as large-volume commercial biofilling capacity has increased significantly since the beginning of the pandemic, drug developers are forced to use inefficient and risky filling methods that leave them with unmet demand. John Harmer (Cytiva’s strategic initiatives leader for aseptic filling) addressed the need for flexibility and capacity for CDMOs and their clients by introducing two gloveless robotic isolator technology…

February 9, 2023

Shaken or Stirred: Comparing Rocking-Motion and Impeller Technology in Cell Cultivation

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For decades, stirred-tank reactors (STRs) have been the gold standard in cell cultivation, particularly in large-scale processes. However, rocking-motion (RM) technology offers an efficient alternative that can be a better choice for certain applications. In a November 2022 webinar, Tobias Schenk (product manager at Sartorius) discussed the two technologies, highlighting the strengths of each and how they can be used in tandem for optimal results. The Presentation RM bioreactor technology mixes nutrients into cell culture media using a wave motion…

February 9, 2023

Cell-Expansion Benefits Using Hollow-Fiber Bioreactor Technology

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In a November 2022 webinar, Stuart Gibb (scientific strategy lead from Terumo Blood and Cell Technologies) explained the benefits of hollow-fiber bioreactors (HFBRs) for cell therapy. They are suitable for both adherent and suspension-adapted cells. Terumo’s bioreactors are designed to enable flexible feeding and waste-management strategies, which are key features that can facilitate optimal cell growth. The Presentation Gibb presented Terumo’s Quantum Flex HFBR platform, which the company launched in September 2022. Bioreactors for the Quantum Flex platform come in…

February 9, 2023

IDT Biologika on the importance of oncolytic viruses in CGT development

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IDT Biologika is a globally operating biopharmaceutical CDMO that specializes in the Contract Development and Manufacturing of vaccines, cell & gene therapeutics including oncolytic viruses, viral vectors, and other biologics for sterile liquid and lyophilized products. Through the utilization of our innovative technologies, we help our clients to advance their prophylactic and therapeutic products to treat serious diseases that impact human health worldwide. How IDT Biologika can support you with Cell & Gene Therapy inquiries was discussed in the following…

February 6, 2023