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Introducing a Multi-Tiered Classification System for Downstream Process Intensification

This webcast features: Martin Lobedann, PhD, Process Technology Consultant, Sartorius. Process intensification in biomanufacturing is becoming more prevalent as market demand for therapies and the cost to deliver them increases. Typically, the move from batch processing to intensified, continuous processing has been seen as an all-or-nothing approach, with little consideration for something in between. Literature concerning process intensification is also relatively crowded, with multiple terms used to describe process intensification like continuous, connected, intensified, or steady-state. Often, these terms are…

Breakthrough in mAbs Processing with State-of-the-Art Chromatographic Clarification

Are you involved in the upstream or downstream processing of mAbs and challenged with inconsistent throughputs between runs and/or at different scales? Are you in search of a solution that can effectively handle high cell densities or high contaminant loads? Are you struggling to find a scalable clarification solution, especially at large scale? Have you considered whether the multiple stages required to achieve acceptable cell culture fluid clarity may be leading to lower product yield and longer process time? If the…

Leveraging dPCR Techniques to Quantitate Lentivirus Particles

This webcast features: Samyuktha Shankar, Scientist II, Field Applications, BioProduction Group, Thermo Fisher Scientific. Digital PCR (dPCR) technology is being increasingly adopted in research, diagnostics, bioproduction, and environmental testing for absolute quantitation of nucleic acids. In this webinar, Thermo Fisher Scientific will discuss leveraging dPCR for absolute quantitation for lentiviral samples. They’ll demonstrate how this technique reduces variability, and improves accuracy and analytical sensitivity, even in high-background conditions. Key Takeaways: Leveraging LTR-based quantitation to enable correlation of total (genomic) and…

Fcγ Receptor and Antigen Kinetic Screening for Rapid Biosimilar Downstream Processing Assessment Using Octet® BLI

Demonstrating biosimilarity throughout upstream and downstream production processes is crucial. However, screening all potential candidates using standard analytical methods can be challenging. To overcome this, an alternative high-throughput analytical approach is needed. In this application note, we showcase the ability to rapidly test a Humira® biosimilar (adalimumab) development sample against three key ligands, meeting regulatory requirements. Our approach involves combining a single analyte kinetic screen of a monoclonal IgG1 antibody against the Fcγ receptors CD16a V176 and CD64, along with…