Upstream & Downstream Processing

Aceto buffers up presence in bioprocessing with A&C buy

A&C Bio Buffer is the sixth acquisition for Aceto in the past two years and signals the firm’s ambitions in the biomanufacturing services space. The deal, financials of which have not been disclosed, brings Aceto a GMP (Good Manufacturing Practices) manufacturer of custom buffer and chemical blend products used in the manufacturing of biopharmaceutical drug products, with a facility in Limerick, Ireland producing over 50 products including biological buffers, process solutions, cleaning solutions and WFI (Water for Injection). “A&C Bio…

Simulated Bed fellows: Tosoh buys purification firm Semba

Tosoh Bioscience says it will complement its resins business through the addition of continuous chromatography firm Semba Biosciences. The deal, which closed earlier this month, saw Pennsylvania-based Tosoh add all Semba’s staff and assets for an undisclosed fee. The acquisition will boost the firm’s downstream bioproduction portfolio, made up of chromatography resins, with the addition of Semba’s simulated moving bed (SMB) chromatography systems (see text box below). “Coupled with Semba’s revolutionary multi-column chromatography technology we have found a perfect complement…

MilliporeSigma says viscosity tech overcomes manufacturing challenges

MilliporeSigma has launched a Viscosity Reduction Excipient Platform, which it says helps tackle production and formulation issues associated with highly concentrated protein solutions. According to Merck’s Life Science business MilliporeSigma, the Viscosity Reduction Platform can address specific needs of different protein-based therapeutics through the combination of amino acids and anionic components. “MilliporeSigma’s new Viscosity Reduction Excipient Platform reduces interactions between proteins (including antibodies) that make the product too thick to pass through an injection needle,” Matthias Bucerius, head of actives and formulation at MilliporeSigma told us. “The platform does…

Gamma invests in bio-sensor and analytics firm Nirrin

Nirrin’s near-infrared spectrometry platform offers a reliable and cost-effective method of real-time analytics and will be leveraged across Gamma’s growing bioprocessing network, the firms says. Gamma Biosciences’s undisclosed investment in Maryland-based Nirrin Technologies brings access to sensors and analytics that support the bioprocess space, including automation tech with real-time, in-process monitoring for upstream and downstream applications. “This is a structured investment with longer term features that allow Nirrin to leverage Gamma’s resources and network in the near term as the…

ABEC launches TFF system it says can triple productivity

ABEC claims its Tangential Flow Filtration (TFF) system offers the largest flow rates and filter areas in the industry in a single-use format. ABEC’s Custom Single Run (CSR) Tangential Flow Filtration (TFF) systems were announced this week as an effort to increase downstream productivity for its bioprocess customers. According to the firm, the CSR TFF achieves flow rates greater than 240 liters per minute across cassette-type filter areas up to 40m2, effectively matching levels seen in stainless steel systems, tripling…

Protein boost for Repligen through $150m Avitide buy

The latest acquisition by Repligen will boost its proteins business, adding bespoke affinity purification ligand manufacturer Avitide. The deal sees bioprocess vendor Repligen Corporation shell out $75 million in cash and $75 million in stock for Lebanon, New Hampshire-headquartered firm Avitide. Avitide is a manufacturer of chromatography resins used in downstream bioproduction and its bespoke commercial offering will bolster Repligen’s own proteins business and its affinity ligand discovery service. Repligen’s legacy proteins business – which includes its Protein A chromatography…

Cytiva makes good on China single-use expansion

Plans to triple single-use component production in China through a longstanding partnership with Wego Pharmaceutical are well underway, says Cytiva. Wego Pharmaceutical Co.’s Weihai, China facility makes single-use bioprocessing consumables on behalf of Cytiva after the two firms forged a partnership in November 2018. The site will expand its capacity through plans envisaged last September but announced last week. “Three new manufacturing lines were launched in under ten months with an additional eight new lines planned to launch in Q3…

Advantages of flexible manufacturing in advanced therapies

With rapid market growth and over 1220 ongoing clinical trials, the need for flexible alternatives is higher than ever. To meet this demand, advanced therapeutic developers are utilizing flexible manufacturing and single-use technologies. This is an abridged version of an article first published as part of the BioProcess Insider ebook, entitled: Cell and Gene Therapies — A 2021 Industry Update. To download the full report, click here. Utilizing flexible systems like premanufactured cleanrooms can reduce costs, construction timelines, and time…

Thermo Fisher doubling single-use capacity through $100m Nashville plant

Thermo Fisher will hire 1,400 staff at the facility in Nashville, Tennessee, which is expected to feed biomanufacturing’s continued demand for single-use technologies. Bioprocess vendor Thermo Fisher Scientific unveiled plans yesterday to bolster its manufacturing network for single-use technology (SUT) products through the construction of a facility in Wilson County, Tennessee. “The new site will be Thermo Fisher’s largest designated SUT manufacturing facility and will help more than double Thermo Fisher’s network manufacturing capacity to support its biopharma customers,” a…

Avantor upping its single-use game in $2.9bn Masterflex buy

Avantor is set to acquire Masterflex, a manufacturer of peristaltic pumps and aseptic single-use fluid transfer tech used in upstream, downstream and fill-finish services. The deal, announced yesterday, “strengthens Avantor’s offering across all bioproduction platforms including monoclonal antibodies (mAbs), cell and gene therapy and mRNA, and supports both therapy and vaccine manufacturing including COVID-19,” the firm said in a statement. The $2.9 billion transaction ($2.7 billion after tax benefits) will add Vernon Hills, Illinois-headquartered tech firm Masterflex to the biopharma…