Voices of Biotech
Podcast: MilliporeSigma says education vital to creating unbreakable chain for sustainability
MilliporeSigma discusses the importance of people, education, and the benefits of embracing discomfort to bolster sustainability efforts.
Sponsored by Emerson
Single-use biopharmaceutical manufacturing systems require gamma-sterilizable, highly stable, accurate, and simple-to-use single-use pH sensors with a long shelf life. Herein we report the design and performance of a single-use pH sensor technology optimized for single-use bag applications such as those found in bioreactor and mixing applications. This technology is the basis of Emerson’s Rosemount 550pH Single-Use Sensor. The sensor is compatible with gamma irradiation and can be attached to a single-use bioreactor bag via industry accepted ports. With the incorporation of a unique storage buffer solution, the sensor has a long shelf life of two years and offers a startup one-point standardization and validation capability without the need for filling the bag.
Sensor prototypes were constructed and tested through real-time aging. It was demonstrated that the sensors remained high performance after two years of storage, with a startup accuracy of ± 0.1 pH at pH 7, a wide pH sensing range between pH 2 and pH 12, a high sensitivity with a response slope higher than 57 mV/pH, and an outstanding sensor stability with drift less than 0.005 pH/day.
Fill out the form below to read the complete special report and learn more about the Rosemount 550pH single-use sensor now.
This special report will be published in BPI’s September 2021 print edition.
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