Voices of Biotech
Podcast: MilliporeSigma says education vital to creating unbreakable chain for sustainability
MilliporeSigma discusses the importance of people, education, and the benefits of embracing discomfort to bolster sustainability efforts.
July 30, 2014
Sponsored by Natrix
NatriFlo™ HD-Q chromatography from Natrix Separations introduces reliable and reproducible Q polish performance that combines resin binding capacity with adsorber speed to achieve a new level of process flexibility. Gallus Biopharmaceuticals (a St. Louis based CMO) evaluated NatriFlo™ HD-Q membrane columns as an anion exchange polishing step with the objective of assessing NatriFlo’s ability to (1) reduce process-derived impurities to achieve target product profile; (2) maintain process robustness to process changes; and (3) achieve reliable scalability from lab to production. This case study illustrates Gallus’ findings, including constant HCP clearance to ~20 ppm across a range of loads (up to 10 kg/L), consistent HCP clearance across device scales, and the ability of the NatriFlo HD-Q membrane to operate robustly with a phosphate buffer system. Gallus’ testing also demonstrated excellent DNA clearance (not covered in this case study).
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