Flow-Through Polishing and the Use of Multimode Ligand Libraries to Improve Process Efficiencies

On May 1, 2019 at the CPhI Theater, Andy Davies, sales and marketing director at Prometic Bioseparations discussed biopharmaceutical separations, and multimode ligands. He shared that there is a trend toward using a very effective capture step — typically using affinity chromatography, where the bulk of purification is done in the initial step. More recently, scientists are beginning to adopt flow-through purification, where the target protein passes through the column, and the contaminants or impurities that still reside in the solution are captured. Multi-mode ligands use has become more common because they are extremely useful in flow-through polishing mode.

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