Affinity chromatography resins employ target-specific ligands attached to a stationary phase and are commonly used to capture therapeutic entities in biologics manufacturing, reducing the number of required purification steps and increasing overall yield.
A less common but powerful use of affinity purification is the removal of problematic impurities, such as host cell proteins. Both techniques require high-specificity affinity ligands with sufficient capacity, stability, and suitability for clinical manufacturing.
In this webinar, we present the development of a novel scavenging resin for clusterin, a persistent CHO host cell protein commonly observed in monoclonal antibody manufacturing processes.
- Understand platform process for the generation of highly specific VHH antibody-based ligands and affinity resin development for bioproduction.
- Analyze performance data and sample chromatography condition for POROSTM CaptureSelectTM ClusterinClear affinity resin.
- Review custom resin development process and timeline.
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