Voices of Biotech
Podcast: MilliporeSigma says education vital to creating unbreakable chain for sustainability
MilliporeSigma discusses the importance of people, education, and the benefits of embracing discomfort to bolster sustainability efforts.
November 10, 2014
Sponsored by WR Grace POSTER
Single-use technology has become increasingly popular in both upstream and downstream biopharmaceutical manufacturing. While there has been substantial adoption of upstream single-use technologies, there continues to be a lag in the development and adoption of single-use technologies in downstream – particularly in chromatography. To help achieve the vision of a completely disposable & flexible manufacturing platform, Grace has developed new high capacity pre-packed disposable protein A columns. The new columns integrate the technologies of Grace silica & surface chemistry with those of Repligen’s rSPA & OPUS® columns. The unique element of the product lies in the optimization of silica and bonding chemistry to maximize dynamic binding capacity while controlling non-specific protein binding. Furthermore, the product demonstrates stability to caustic cycling within a single-campaign use. Most importantly, the incompressible silica substrate ensures scalable performance regardless of column size & flow rates allowing for further productivity improvements in purification run times. Overall, this plug-and-play single-use chromatography solution represents the missing link in enabling a fully disposable MAb manufacturing platform.
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