POROS™ XQ is a next-generation strong anion- exchange resin with a fully quaternized amine surface chemistry. It was designed to retain all the beneficial performance attributes of POROS HQ resin, such as resolution capability, flow properties, and physical stability, with the added benefits of higher capacity and salt tolerance. Those were realized by optimizing the pore structure, which drives better access of biomolecules to the surface charge, and by optimizing the amount of surface charge (the ligand density) as measured by ionic capacity. Better access to a higher amount of ionic capacity increases dynamic binding capacity (DBC) and improves salt tolerance, because the resin can withstand higher amounts of counterion and still allow effective protein binding.
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