Raman spectroscopy is used in biomanufacturing as a process analytical technology (PAT) tool for making rapid, nondestructive, in-process measurements. However, Raman data collection at early stages of bioprocess development has been a challenge because of the lack of interface to bioreactors <250 mL. Realizing the industry was struggling to capitalize on the full potential of Raman spectroscopy, Kaiser Optical Systems, Inc. (Kaiser), an Endress+Hauser company, collaborated with Sartorius to bring Raman to Ambr 15 microbioreactors (10â€“15 mL) and Ambr 250 minibioreactors (100â€“250 mL). Sartoriusâ€™s new BioPAT Spectro platform enables Kaiser Ramanâ€“based quality by design (QbD) early in process development and scales up to Biostat STR single-use bioreactors.
The following Q&A explains how Kaiser Raman technology and the BioPAT Spectro platform by Sartorius work together to provide biopharmaceutical manufacturers with scalable, real-time bioprocess monitoring.
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