The Effect of Membrane Selection and Operating Parameters on Sterile Filtration of Hyaluronic Acid

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Hyaluronic acid (HA)-based solutions are traditionally difficult to filter, due to their high viscosity. Many users have found sterile filtration of hyaluronic acid solutions very challenging to implement, from both an economical, as well as a practical standpoint. This White Paper evaluates commercially-available sterilizing-grade products for filtration of HA and explains how sterilizing-grade filters can offer a highly efficient, economical solution even under the worst-case bacterial challenge conditions. It outlines how the combination of various properties of HA-based solutions and filtration conditions can have a clear impact on filtration performance independent of membrane selection, and provides guidance on how adjustments and optimization of these process parameters can contribute to filtration improvement.

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