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Building Reliability Into Scale-Up: Targeted Optimization for AAV Production
BPI Contributor
September 17, 2024
40 Min View
Date: Sep 17, 2024
Duration: 40 Min
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Sponsored by Sartorius
This webcast features: Ahmed Youssef, Senior Manager, Upstream Process Development, Ascend Advanced Therapies & Ivana Petrović Koshmak, Head of Upstream Process Development, Sartorius.
Scaling up AAV production presents challenges that impact performance and product quality.
In this webinar, experts from Sartorius and Ascend Advanced Therapies will share insights on AAV process optimization and scale-up, including strategies to maximize AAV yield and ensure consistency across scales.
Key Takeaways:
Learn how a DOE approach and high quality raw materials can streamline process development.
Explore AAV production scaling from 250 mL to 200 L in geometrically consistent bioreactors.
Evaluate the performance of a dual plasmid versus triple transfection.
Discover how key factors (e.g., mixing, oxygen transfer, & volumes) impact performance.
Register or Login and hit Watch on Demand to view the recorded webcast now.
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