July 1, 2015
EMD Millipore, the Life Science business of Merck KGaA of Darmstadt, Germany, today introduced the Mobius® 2000 liter single-use bioreactor. The 2000 liter bioreactor joins the Mobius® stirred tank bioreactor portfolio (from 3 to 2000 liters) that provides the ultimate in flexibility, scalability, and convenience. With configurable software, hardware, and single-use Flexware® assemblies for suspension and adherent cell culture applications, the new 2000 liter single-use bioreactor incorporates industry-leading design features that enable users to easily optimize their upstream process.
The new Mobius® 2000 liter single-use bioreactor features the industry’s first pull-out drawer and self-deploying bag, making Flexware® assembly installation and inflation safe and easy. This design minimizes operator intervention and requires no hoist during Flexware® assembly installation and removal. A patent-pending baffle design creates superior, homogenous mixing. The 5:1 turndown ratio allows users to inoculate and harvest at lower volumes, creating a wider, more flexible process window for seeding, growth, and collection strategies.
The Mobius® 2000 liter single-use bioreactor includes an external SensorReady loop connected to the Flexware® assembly via Lynx® connectors to provide greater flexibility and confidence for process monitoring and control. Unlike traditional bioreactors in which sensors are inserted into the Flexware® assembly, the SensorReady loop enables users to incorporate additional sensors without modifying the Flexware® assembly.
The Mobius® 2000 liter single-use bioreactor can be supplied as a fully-integrated system with intuitive GMP-compliant software that reduces the learning curve for operators and allows for easy integration into plant automation strategies. The automation is simple and enables users to easily customize and control their processes. For customers with plant-wide common automation strategies, the single-use bioreactor can be integrated into third party automation platforms.
“Successful development of upstream processes demands flexibility, scalability and ease of use,” said Udit Batra, president and CEO, EMD Millipore. “Our ground-breaking Mobius® 2000 liter single-use bioreactor delivers these essential benefits, including superior mixing, 5:1 turndown ratio, and critical ease of use. Our complete upstream and downstream portfolio supports GMP production and allows our customers to move molecules faster and more reliably into the clinic and to market.”
The Mobius® 2000 liter single-use bioreactor joins the 3, 50, and 200 liter Mobius® single-use bioreactors, and is just one of the Company’s new additions to a comprehensive portfolio of products to optimize, streamline, and accelerate drug development and production. Recently introduced products include:
Cellvento® CHO cell culture media and companion feed formulations allow selection of the optimal media formulation for a given application, tailored for specific CHO cell lines. Available in liquid and powder form, the chemically defined, non-animal-origin media deliver superior cell growth and productivity in batch, fed-batch mode, and perfusion applications.
The NovaSeptum single-use preloaded holder, pre-loaded with flat bags, bottles, or AV syringes, is ideal for aseptic and sterile processes. The closed design ensures the sample is isolated from point of sample to analysis. The high purity sampling units are suited for a variety of applications including sterility, bioburden and endotoxin testing, chemical analysis, and applications requiring very low affinity for proteins, complex carbohydrates or small molecules.
Clarisolve® depth filters process pretreated feeds in a significantly reduced footprint without the need for a secondary stage of clarification. Clarisolve® depth filters eliminate the need for centrifugation, enabling a fully single-use process train, and considerably reduces the pre-use flushing requirements. This technology was developed to address the shortcomings of traditional downstream clarification approaches when processing high cell density and high titer cell cultures.
For more information on the Mobius® 2000 liter single-use bioreactor and other Mobius® products, please visit www.emdmillipore.com/MobiusTwist.
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