Innovative Impurity Reduction in Harvesting Process With TREHALOSE SG

Host cell proteins (HCPs) are proteins that are unintentionally introduced from the host cells during the manufacturing process of biopharmaceuticals. The importance of impurity management in final products cannot be overstated. Advances in upstream processing have led to increased carry-over of host cell-derived impurities into downstream processing, posing significant challenges. The Nagase Viita study addresses these challenges with innovative solutions.

Trehalose is known to protect cells and proteins from various physical stresses. Our research explores its role in reducing impurities during the antibody harvesting process, providing new insights into its applications.

In the document, you will discover:

In this experiment, CHO cells were cultured, and data were obtained from two Tangential Flow Filtration (TFF) processes. The results were then compared with the control to evaluate the efficiency and effectiveness of TREHALOSE SG in the TFF processes for reducing impurities.

The biopharmaceutical industry is increasingly focusing on advanced analytical methods and comprehensive impurity profiling to meet regulatory requirements and ensure product quality.

This innovative approach offers a new perspective on impurity management in biopharmaceutical manufacturing.