Friday January 22, 2021
  • |Subscribe
  • |Contribute
  • |About
  • |Access Your Account
  • |Register
  • |Login
  • |Home
  • |Current Issue
  • |Issue Archive
    • |Featured Reports
    • |eBooks
  • |BioProcess Insider
  • |Multimedia
    • |BPI White Papers
    • |Webinars
    • |Posters
  • |BioProcess International Events
    • |BioProcess International West
    • |COVID-19 Therapeutic Development & Production
  • |BioProcess International Academy
  • |Events

BioProcess International

Covering the whole development process for the global biotechnology industry

  • Upstream
    Processing
    Bioprocessing begins upstream, most often with culturing of animal or microbial cells in a range of vessel types (such as bags or stirred tanks) using different controlled feeding, aerating, and process strategies.
    • Assays
    • Biochemicals/Raw Materials
    • Bioreactors
    • Cell Culture Media
    • Expression Platforms
    • Fermentation
    • Perfusion Cell Culture
    • Upstream Contract Services
    • Upstream Single-Use Technologies
  • Downstream
    Processing
    Beginning with harvest of material from a bioreactor, downstream processing removes or reduces contaminants to acceptable levels through several steps that typically include centrifugation, filtration, and/or chromatographic technologies.
    • Filtration
    • Separation/Purification
    • Viral Clearance
    • Chromatography
    • Downstream Contract Services
    • Downstream Single-Use Technologies
  • Manufacturing
    Drug products combine active pharmaceutical ingredients with excipients in a final formulation for delivery to patients in liquid or lyophilized (freeze-dried) packaged forms — with the latter requiring reconstitution in the clinical setting.
    • Personalized Medicine
    • Single Use
    • Supply Chain
    • Vaccines
    • MAb
    • Biosimilars
    • Cell/Gene Therapies
    • Emerging Therapeutics
    • Facility Design/Engineering
    • Continuous Bioprocessing
    • Fill/Finish
    • Formulation
    • Information Technology
    • Manufacturing Contract Services
    • Process Monitoring and Controls
  • Analytical
    Many technologies are used to characterize biological products, manufacturing processes, and raw materials. The number of options and applications is growing every day — with quality by design (QbD) giving impetus to this expansion.
    • Culture Development
    • Cell Line Development
    • Downstream Development
    • Downstream Validation
    • Laboratory Equipment
    • PAT
    • Pre-Formulation
    • Product Characterization
    • QA/QC
    • Upstream Development
    • Upstream Validation
    • Leachables/Extractables/Particulates
  • Business
    Even as it matures, the biopharmaceutical industry is still a highly entrepreneurial one. Partnerships of many kinds — from outsourcing to licensing agreements to consultancies — help companies navigate this increasingly global business environment.
    • Careers
    • CMC Forums
    • Economics
    • Intellectual Property
    • Pre-Clinical and Clinical Trials
    • Regulatory Affairs
    • Risk Management
    • BioRegions

READ NOW Read Now Read Now Read Now Read Now Download Now

Featured Content

Moderna has the capacity but cannot guarantee the supply of COVID-19 vaccine

Moderna says it has the capacity to deliver one billion doses of COVID-19 vaccine, mRNA-1273 but is concerned with raw material supply.

Read Now

Accelerating Clinical Development and Commericalization with a Lentiviral Vector Platform Manufacturing Process for Cell Therapy

Sponsored Lentigen's lentivirus vector platform using serum-free suspension for development and commercialization of advanced therapies exhibits a strong CMC profile

Read Now

Reduce Downstream Processing Costs for MAbs By Switching to a Two-Step Platform

Sponsored Toyopearl NH2-750F anion-exchange resin is ideal for intermediate purification of mAbs, removing all impurities in one flow-through polishing step.

Read Now

eBook: Antibody–Drug Conjugates — Refining Product Designs for Improved Outcomes

Researchers optimizing antibody–drug conjugates by tweaking drug payloads, chemical linkers, and mechanisms of cellular uptake.

Read Now

Anticipating Cell-Line Challenges to Drive CMC Readiness

The bioprocessing industry must investigate CHO cell line traits further to learn more about their productivity, recovery time, scalability, and stability.

Read Now

The Therapeutic Monoclonal Antibody Product Market

Market and approval trends indicate that MAb products will continue to be a dominant biotherapeutic modality for the foreseeable future.

Read Now

Case Study for a Facility-Fit Driven Process Development

Sponsored Considering facility fit constraints during process development can facilitate technology transfer and shorten delivery times to clients.

Read Now

Next-Generation Biotechnology Product Development, Manufacturing, and Control Strategies, Part 1: Upstream and Downstream Strategies

A CASSS CMC Forum from July 2018 sought to develop strategies for shortening development times for products in the biologics pipeline.

Read Now

Ask the Expert Webcasts

On-Demand Webcasts

  • Protein A Chromatography: Using Automation Instead of Multiple Columns To Increase Productivity
  • Technology-Ready Processes for Gene Therapy Manufacturing 2.0

More >>

BioProcess Insider News and Analysis

@bioprocessintl Tweets

  • Tweet Avatar @BPI_TechEditor recently spoke with Pavan Kumar Kunala of Almac Sciences (part of @AlmacGroup) about expanded… https://t.co/p3N6NYm0H2 13 hours ago
    Reply Retweet Favourite
  • Tweet Avatar This report from writers at @WuXiBiologics explains why now is the "watershed moment" for development and manufactu… https://t.co/Hwrs0OUEy5 13 hours ago
    Reply Retweet Favourite
Follow @bioprocessintl

Upstream Processing

Product Quality Attribute Shifts in Perfusion Systems, Part 2: Elucidating Cellular Mechanisms

Intensified Seed Train Strategy for Faster, Cost-Effective Scale-Up of Biologics Manufacturing

See all in Upstream Processing

Downstream Processing

Nontargeted HCP Monitoring in Downstream Process Samples: Combining Micro Pillar Array Columns with Mass Spectrometry

eBook: Ion-Exchange Chromatography for Modern Biopharmaceutical Purification

See all in Downstream Processing

White Papers

Fragment-Based Screening in Drug Discovery: How to Improve Hit Rates & Deliver Higher-Value Targets

Enabling Vaccine Production: Solving Challenges

Single-Use Systems: Globalizing Best Practices and Technology Specifications

Keep Your HCPs Under Control

Manufacturing Pluripotent Cell Therapeutics

Your Guide to Efficiently Develop Antibody-Based Therapeutics

Scalability of Lentiviral Production with the CTS LV-MAX Lentiviral Production System in Bioreactors

Technology Transfers – A Beginner’s Guide

Previous
Next
See all Papers

Manufacturing

Reducing Risk in Bioproduction with Facilities Equivalency

Optimization of Processes and Advanced Platforms for Viral Vector Processing

See all in Manufacturing

Analytical

eBook: Biomarkers — Improving Clinical Studies to Enhance Commercial Success for Biologics

Making Safe and Effective CAR T Cells: How Droplet Digital PCR Can Improve Their Quality Control

See all in Analytical

Posters

Evaluation Of a New Glucose Control Strategy Using CITSens Bio APC (Automated Process Control) for CHO Fed-Batch Application

High Productivity and Process Economy in GxP Applications with the Octet™ Platform

Accelerate Cell and Gene Therapy Development and Manufacturing with Fully Integrated Closed CAR-T Cell Therapy Platform

Characterization Platform for Structural and Functional Feature Investigation of Bispecific Molecules

Automated Cell Line Development With Greater Than 99% Monoclonality On the Beacon® Platform

High Titer Recombinant Lentivirus and Adeno-associated Virus Production for Therapeutic Applications

New Approach for Qualifying Liquid Handling in Single-Use Bags

Antibody Affinity Extraction Enables Identification of Host Cell Proteins by Mass Spectrometry

Previous
Next
See all Posters

Webinars

AAV Suspension Platform Generations: Continuous Improvement Leading to Increased Viral Vector Titer and Yield

Exploring New and Improved Analytical Methods for Traditional and Unique Modalities

Analytical Ultracentrifugation for Characterization of AAV Gene Delivery Vectors

Opto-Sensor Guided Centrifugation for Efficient, Reagent-Free Cell Separation in a Semi-Automated Closed System

De-Risking INDs with Unrivaled Monoclonality Assurance in Cell Line Development

How to Halve the Costs of Antibody Purification?

Best Practices for Ensuring High Virus Clearance When Using Anion Exchange Membrane Adsorbers

Configurable, Single-Use TFF Systems for Rapid Bioprocessing

Previous
Next
See all Webinars

Trending

Sorry. No data so far.

Explore Topics

  • Upstream Processing
  • Downstream Processing
  • Manufacturing
  • Analytical
  • Business

Publication

  • Issue Archive
  • Featured Reports
  • eBooks
  • Subscribe
Connect
Privacy policy

BioProcessIntl.com

  • White Papers
  • Posters
  • Webinars
  • BPI Theater
  • Awards
  • Register
  • Login
  • Access Your Account

Keep up with BPI

  • Email Newsletters
  • Events
  • BioProcess Insider
  • Twitter
  • LinkedIn

About BPI

  • Who We Are
  • Editorial Advisors
  • Author Guidelines
  • Advertising/Media Kit
  • List Rental/Reprints
  • Contact Us
  • Careers
BPI
twitter linkedin
Site Map|Contact
©2021 BioProcess International All Rights reserved
  • Home
  • Current Issue
  • Issue Archive
    â–¼
    • Featured Reports
    • eBooks
  • BioProcess Insider
  • Multimedia
    â–¼
    • BPI White Papers
    • Webinars
    • Posters
  • BioProcess International Events
    â–¼
    • BioProcess International West
    • COVID-19 Therapeutic Development & Production
  • BioProcess International Academy
  • Events