Thursday February 25, 2021
  • |Subscribe
  • |Contribute
  • |About
  • |Access Your Account
  • |Register
  • |Login
  • |Home
  • |Current Issue
  • |Issue Archive
    • |Featured Reports
    • |eBooks
  • |BioProcess Insider
  • |Multimedia
    • |BPI White Papers
    • |Webinars
    • |Posters
  • |BioProcess International Events
    • |BioProcess International West
    • |COVID-19 Therapeutic Development & Production
  • |BioProcess International Academy
  • |Events

BioProcess International

Covering the whole development process for the global biotechnology industry

  • Upstream
    Processing
    Bioprocessing begins upstream, most often with culturing of animal or microbial cells in a range of vessel types (such as bags or stirred tanks) using different controlled feeding, aerating, and process strategies.
    • Assays
    • Biochemicals/Raw Materials
    • Bioreactors
    • Cell Culture Media
    • Expression Platforms
    • Fermentation
    • Perfusion Cell Culture
    • Upstream Contract Services
    • Upstream Single-Use Technologies
  • Downstream
    Processing
    Beginning with harvest of material from a bioreactor, downstream processing removes or reduces contaminants to acceptable levels through several steps that typically include centrifugation, filtration, and/or chromatographic technologies.
    • Filtration
    • Separation/Purification
    • Viral Clearance
    • Chromatography
    • Downstream Contract Services
    • Downstream Single-Use Technologies
  • Manufacturing
    Drug products combine active pharmaceutical ingredients with excipients in a final formulation for delivery to patients in liquid or lyophilized (freeze-dried) packaged forms — with the latter requiring reconstitution in the clinical setting.
    • Personalized Medicine
    • Single Use
    • Supply Chain
    • Vaccines
    • MAb
    • Biosimilars
    • Cell/Gene Therapies
    • Emerging Therapeutics
    • Facility Design/Engineering
    • Continuous Bioprocessing
    • Fill/Finish
    • Formulation
    • Information Technology
    • Manufacturing Contract Services
    • Process Monitoring and Controls
  • Analytical
    Many technologies are used to characterize biological products, manufacturing processes, and raw materials. The number of options and applications is growing every day — with quality by design (QbD) giving impetus to this expansion.
    • Culture Development
    • Cell Line Development
    • Downstream Development
    • Downstream Validation
    • Laboratory Equipment
    • PAT
    • Pre-Formulation
    • Product Characterization
    • QA/QC
    • Upstream Development
    • Upstream Validation
    • Leachables/Extractables/Particulates
  • Business
    Even as it matures, the biopharmaceutical industry is still a highly entrepreneurial one. Partnerships of many kinds — from outsourcing to licensing agreements to consultancies — help companies navigate this increasingly global business environment.
    • Careers
    • CMC Forums
    • Economics
    • Intellectual Property
    • Pre-Clinical and Clinical Trials
    • Regulatory Affairs
    • Risk Management
    • BioRegions

Read Now Read Now Read Now READ NOW Read Now Download Now

Featured Content

Podcast: Industry veteran moves to Lykan Bioscience, and this time its personal!

The BioProcess Insider Expression Platform explores the evolution of cell and gene therapies with COO of Lykan Bioscience, Patrick Lucy.

Read Now

From Target to Hit: The WuXi HitS Platform

Sponsored WuXi's HiTS business unit has constructed >200 DNA-encoded libraries displaying >90 billion different small-molecule structures.

Read Now

G-Protein–Coupled Receptors: Promising Targets for Antibody–Drug Conjugates

Improved understanding of the structure and function of GPCRs in cancer is accelerating development of novel ADCs for cancer treatment.

Read Now

eBook: Biomarkers — Improving Clinical Studies to Enhance Commercial Success for Biologics

Finding predictive biomarkers for cancer and autoimmune diseases could help drug companies hone clinical trials and improve patient outcomes.

Read Now

Drug Formulations Are Changing:
New Sterile Filtration Challenges in the Changing Landscape of Drug Formulations

Sponsored Complex drug formulations are raising sterile filtration challenges that require new strategies for meeting process development timelines.

Read Now

Manufacture and Regulation of Cell, Gene, and Tissue Therapies, Part 1: Chemistry, Manufacturing, and Control Challenges

An adequately controlled system for raw materials, starting materials, and reagents is the foundation for manufacturing of ATMPs.

Read Now

Innovations in the Manufacturing of Cell and Gene Therapies

Sponsored Integrating platforms for development, testing, manufacturing, and commercialization can accelerate time to market and can be achieved by advanced therapies contract manufacturing.

Read Now

Next-Generation Biotechnology Product Development, Manufacturing, and Control Strategies, Part 2: Process Modeling and Analytics

Advancements in data analytics and process modeling are driving efforts to transform biopharmaceutical process control strategies.

Read Now

Ask the Expert Webcasts

On-Demand Webcasts

  • 2.5× Lentiviral Vector Bioreactor Yield Increase and Simplified Execution with Innovative Tangential-Flow Depth Filtration
  • Optimizing Your Excipient Screening for Vaccine Formulation with an Ultra-Pure Pharmaceutical Gelatin

More >>

BioProcess Insider News and Analysis

@bioprocessintl Tweets

  • Tweet Avatar In this Special Report, Chad Schwartz from @thermofisher discusses the importance of equivalency and the strategies… https://t.co/tMAjfMAEXS 8 hours ago
    Reply Retweet Favourite
  • Tweet Avatar RT @Dan5tanton: Having its own plasmid DNA capabilities will launch Catalent into areas like mRNA and non-viral gene delivery, the… https://t.co/kb1lYFhLg8 9 hours ago
    Reply Retweet Favourite
Follow @bioprocessintl

Upstream Processing

Oxygen Control Strategy and Yield of Recombinant Antibody Fragments Produced in Fermentation

Bioreactor Automation Driven by Real-Time Sensing: Enhancing Productivity Through Accurate, Efficient Glucose Control

See all in Upstream Processing

Downstream Processing

Removing Oligomers of a Recombinant Human Therapeutic Hormone:
Evaluation of Chromatographic Options for Effectiveness

Evaluation of a Novel Peptide-Based Affinity Ligand for Human IgM Purification: Use of an Automated Liquid-Handling System for Rapid Assessment of Binding...

See all in Downstream Processing

White Papers

Transfection Reagents for Cell and Gene Therapy

FAQs: Challenging host cell protein assays for improved risk mitigation

Fragment-Based Screening in Drug Discovery: How to Improve Hit Rates & Deliver Higher-Value Targets

Enabling Vaccine Production: Solving Challenges

Single-Use Systems: Globalizing Best Practices and Technology Specifications

Keep Your HCPs Under Control

Manufacturing Pluripotent Cell Therapeutics

Your Guide to Efficiently Develop Antibody-Based Therapeutics

Previous
Next
See all Papers

Manufacturing

Exciting Starts for New Players and Platforms: Nucleic-Acid Vaccines Prepare for Their Commercial Debut

Cold-Chain Validation: Emerging Vaccines for COVID-19 and Beyond Require More Extensive Evaluation

See all in Manufacturing

Analytical

Advanced Analytics to Accelerate Development of Genetic Vaccines

A Universal Assay Determination Method for Antisense Oligonucleotides: A New Slope Spectroscopy Method

See all in Analytical

Posters

Evaluation Of a New Glucose Control Strategy Using CITSens Bio APC (Automated Process Control) for CHO Fed-Batch Application

High Productivity and Process Economy in GxP Applications with the Octet™ Platform

Accelerate Cell and Gene Therapy Development and Manufacturing with Fully Integrated Closed CAR-T Cell Therapy Platform

Characterization Platform for Structural and Functional Feature Investigation of Bispecific Molecules

Automated Cell Line Development With Greater Than 99% Monoclonality On the Beacon® Platform

High Titer Recombinant Lentivirus and Adeno-associated Virus Production for Therapeutic Applications

New Approach for Qualifying Liquid Handling in Single-Use Bags

Antibody Affinity Extraction Enables Identification of Host Cell Proteins by Mass Spectrometry

Previous
Next
See all Posters

Webinars

Integrated mRNA Production Process from E. coli to Highly Purified mRNA

Lentiviral Vector Platform Generation: Increase Titer and Yield with Greater Predictability

Improving and Intensifying Vaccine Purification By Implementing Affinity Chromatography

AAV Suspension Platform Generations: Continuous Improvement Leading to Increased Viral Vector Titer and Yield

Exploring New and Improved Analytical Methods for Traditional and Unique Modalities

Analytical Ultracentrifugation for Characterization of AAV Gene Delivery Vectors

Opto-Sensor Guided Centrifugation for Efficient, Reagent-Free Cell Separation in a Semi-Automated Closed System

De-Risking INDs with Unrivaled Monoclonality Assurance in Cell Line Development

Previous
Next
See all Webinars

Trending

  • Manufacturing

    eBook: Formulation, Fill–Finish — Biopharmaceutical Drug-Product Trends and Technologies

  • Manufacturing

    Silicone Tubing for Biopharmaceutical Applications: Particulates, Endotoxins, and Bioburden Characterization

  • Manufacturing

    The Green Imperative: Part Two — Engineering for Sustainability in Single-Use Technologies

  • Upstream Processing

    Bioreactor Automation Driven by Real-Time Sensing: Enhancing Productivity Through Accurate, Efficient Glucose Control

Explore Topics

  • Upstream Processing
  • Downstream Processing
  • Manufacturing
  • Analytical
  • Business

Publication

  • Issue Archive
  • Featured Reports
  • eBooks
  • Subscribe
Connect
Privacy policy

BioProcessIntl.com

  • White Papers
  • Posters
  • Webinars
  • BPI Theater
  • Awards
  • Register
  • Login
  • Access Your Account

Keep up with BPI

  • Email Newsletters
  • Events
  • BioProcess Insider
  • Twitter
  • LinkedIn

About BPI

  • Who We Are
  • Editorial Advisors
  • Author Guidelines
  • Advertising/Media Kit
  • List Rental/Reprints
  • Contact Us
  • Careers
BPI
twitter linkedin
Site Map|Contact
©2021 BioProcess International All Rights reserved
  • Home
  • Current Issue
  • Issue Archive
    â–¼
    • Featured Reports
    • eBooks
  • BioProcess Insider
  • Multimedia
    â–¼
    • BPI White Papers
    • Webinars
    • Posters
  • BioProcess International Events
    â–¼
    • BioProcess International West
    • COVID-19 Therapeutic Development & Production
  • BioProcess International Academy
  • Events