Friday January 27, 2023
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BioProcess International

Covering the whole development process for the global biotechnology industry

  • Upstream
    Processing
    Bioprocessing begins upstream, most often with culturing of animal or microbial cells in a range of vessel types (such as bags or stirred tanks) using different controlled feeding, aerating, and process strategies.
    • Assays
    • Biochemicals/Raw Materials
    • Bioreactors
    • Cell Culture Media
    • Expression Platforms
    • Fermentation
    • Perfusion Cell Culture
    • Upstream Contract Services
    • Upstream Single-Use Technologies
  • Downstream
    Processing
    Beginning with harvest of material from a bioreactor, downstream processing removes or reduces contaminants to acceptable levels through several steps that typically include centrifugation, filtration, and/or chromatographic technologies.
    • Filtration
    • Separation/Purification
    • Viral Clearance
    • Chromatography
    • Downstream Contract Services
    • Downstream Single-Use Technologies
  • Manufacturing
    Drug products combine active pharmaceutical ingredients with excipients in a final formulation for delivery to patients in liquid or lyophilized (freeze-dried) packaged forms — with the latter requiring reconstitution in the clinical setting.
    • Biosimilars
    • Cell/Gene Therapies
    • Continuous Bioprocessing
    • Emerging Therapeutics
    • Facility Design/Engineering
    • Fill/Finish
    • Formulation
    • Information Technology
    • MAb
    • Manufacturing Contract Services
    • Personalized Medicine
    • Process Monitoring and Controls
    • Single Use
    • Supply Chain
    • Vaccines
    • Validation
  • Analytical
    Many technologies are used to characterize biological products, manufacturing processes, and raw materials. The number of options and applications is growing every day — with quality by design (QbD) giving impetus to this expansion.
    • Culture Development
    • Cell Line Development
    • Downstream Development
    • Downstream Validation
    • Laboratory Equipment
    • PAT
    • Pre-Formulation
    • Product Characterization
    • QA/QC
    • Upstream Development
    • Upstream Validation
    • Leachables/Extractables/Particulates
  • Business
    Even as it matures, the biopharmaceutical industry is still a highly entrepreneurial one. Partnerships of many kinds — from outsourcing to licensing agreements to consultancies — help companies navigate this increasingly global business environment.
    • Careers
    • CMC Forums
    • Economics
    • Intellectual Property
    • Pre-Clinical and Clinical Trials
    • Regulatory Affairs
    • Risk Management
    • BioRegions

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Featured Content

Podcast: Lumen using spirulina to make ‘edible’ antibody drugs

Lumen Biosciences hopes to use its spirulina-based platform to develop drugs targeting gastrointestinal disorders.

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eBook: A Dynamic Control Strategy for Downstream Continuous Bioprocessing

Implementing surge tanks could address the biopharmaceutical industry's urgent need for dynamic control of continuous downstream processes.

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The CRISPR Saga (So Far)

The provenance of eukaryotic CRISPR has not been settled for good by the Patent Trial and Appeal Board. There are four parties involved: CVC, Broad, ToolGen Inc. and Sigma-Aldrich Co.

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The Unique Properties of Gelatin in 3D Bioprinting

Sponsored 3D bioprinting is a very popular tissue engineering technology used in the field of regenerative medicine.

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Cold Chain Excellence: Getting Control Over Freezing of Biologics

Sponsored This special report from Single Use Support GmbH discusses how single-use systems can provide solutions for controlling biologics freezing.

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Plant-Based Protein Expression: Emerging Systems Bring Viable Approaches to Biopharmaceutical Manufacturing

The application of plant-based expression systems to produce biopharmaceuticals for human and veterinary indications are proving to be safe for clinical use.

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Scaling AAV Production: Easing the Transition from Laboratory Scales to Commercial Manufacturing

Best practices for scaling AAV production comes from the importance of identifying and monitoring critical quality attributes (CQAs).

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The Impact of Protein Stability on Virus Filtration

Sponsored This special report on virus filtration by scientists at Pall Biotech includes discussion of minimizing protein aggregation through formulation and handling considerations.

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Ask the Expert Webcasts

On-Demand Webcasts

  • Practical Approaches to Metals Analysis of Cell Culture Media & Impact on Therapeutic Protein Production Using ICP-MS
  • Adenovirus Vector Manufacturing Platform Using CIMmultus QA

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BioProcess Insider News and Analysis

@bioprocessintl Tweets

  • Tweet Avatar Join us today for a #BPIAskTheExpert on "Benefits of Real-Time Analytics to Overcome Common Cell Culture Challenges… https://t.co/dr0bbAydNm 17 hours ago
  • Tweet Avatar Take a look at this special report, "Improving Scalability of AAV and Lentivirus Production: Tailored Transfection… https://t.co/RoRdsLhLh9 18 hours ago

Upstream Processing

Deciphering Nutritional Needs in Bioprocess Optimization: Targeted and Untargeted Metabolomics with Genome-Scale Modeling

Recombinant Protein Expression with a Baculovirus–Insect Cell System

See all in Upstream Processing

Downstream Processing

Triton X-100 Elimination: The Road Ahead for Viral Inactivation

Hollow-Fiber Nanofiltration for Robust Viral Clearance of Non-MAb Biologics

See all in Downstream Processing

White Papers

Magnetic Agitators Score on Climate Friendliness

From Concept to Cure: Using AAV in Gene Therapy

Solving Cost and Supply Challenges in Biopharma Downstream Processing

Leading Biopharma Uses Linkit® AX: Here are the Results

Intensified Biomanufacturing: Achieving 3-4-Fold Higher Titers of mAbs Using Syngene’s Intensified Fed-Batch Process

Drug Development – Developing Biologics for Respiratory Delivery

Critical Steps to Consider During Customized Host Cell Protein (HCP) ELISA Development

From Integrated Engineering to Integrated Operations: Solutions For Live Operation

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Manufacturing

eBook: mRNA — Negotiating New Manufacturing Hurdles

Cell Therapy — Supply Chain Discussions

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Analytical

The State of Quality Risk Management in the Pharmaceutical Industry: Commentary on the Draft ICH Q9 Revision

Investigation of HCP Enrichment During CGMP Scale-Up

See all in Analytical

Posters

Accelerating Cell Line Development with an Efficient, Combined Platform Approach

Kuhner TOM For Off-Gas Analysis in Shake Flasks

Evaluation Of a New Glucose Control Strategy Using CITSens Bio APC (Automated Process Control) for CHO Fed-Batch Application

High Productivity and Process Economy in GxP Applications with the Octet™ Platform

Accelerate Cell and Gene Therapy Development and Manufacturing with Fully Integrated Closed CAR-T Cell Therapy Platform

Characterization Platform for Structural and Functional Feature Investigation of Bispecific Molecules

Automated Cell Line Development With Greater Than 99% Monoclonality On the Beacon® Platform

High Titer Recombinant Lentivirus and Adeno-associated Virus Production for Therapeutic Applications

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Webinars

Benefits of Real-Time Analytics to Overcome Common Cell Culture Challenges

Simplify Residual DNA Quantitation in Viral Vector Production With qPCR and dPCR Tools

Simple In-House Mycoplasma Testing Method for Regulatory Expectations and Rapid, Confident, and Actionable Results

The BARDA Industry Day Breakdown

Grow Your CDMO With the Addition of Gloveless, Robotic Aseptic Filling

Residual DNA/Protein and Mycoplasma Detection in Cell and Gene Therapy Products

Ensuring Leak-Free Performance During Tissue Container Shipping Utilizing ASTM D4991

Benefits of Hollow Fiber Filter Cell Expansion

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