Single-Use Technologies: Innovation and Performance

“Aggressive Microbial Production from Inoculation Through Harvest in Single-Use Systems,” with Dmitrij Bugajev and Jason D. BrownOctober 22, 2020Watch NowSingle-use fermentors enable production facilities to utilize single-use technologies instead of traditional stainless-steel fermentor vessels, achieving equivalent expression with rapidly growing high-density cultures. We will compare some results from various processes with yeast and bacteria before and after technology transferred to single-use at our two facilities. We will give you our feedback as previous end users of stainless-steel fermentors and now of single-use fermentors along with things to considerations that might help you make your transition smooth. We also will discuss single-use processing benefits and time-saving advantages to simplify closed-system production from inoculation through harvest and initial downstream processing. You will learn about:

“Bioprocess Selection and Economics: 5,000-L DynaDrive™ Bioreactor Shifting the Paradigm,” with Jeff Johnson, Mark Thomas Smith, and Kevin MullenNovember 12, 2020Watch NowSingle-use technologies enable a flexibility and modularity effectively unattainable with more traditional stainless-steel technologies, particularly in upstream bioprocesses. Single-use bioreactors up to 2,000 L are employed largely in preclinical- and clinical-stage bioprocesses to leverage this flexibility. As products reach commercial maturity, scales larger than 2,000 L frequently become desirable to take advantage of economies of scale. With the typical upper limit of single-use bioreactors at 2,000 L, this has traditionally meant transfer to stainless-steel systems. The introduction of the Thermo Fisher Scientific HyPerforma™ DynaDrive™ 5,000-L bioreactor opens a new paradigm of operation in terms of volume, while providing unprecedented ergonomics and flexibility. In tandem with Thermo Fisher, Jeff Johnson (former head of Merck Single-Use Network) has evaluated the operational and economic implications of this new reactor system and shares his perspective of how the biopharma industry might change with the introduction of the DynaDrive system. Kevin Mullen (Senior Product Manager) introduces the DynaDrive systems, and Mark Thomas Smith (Staff R&D Engineer) explores how this technology can meet the demands of intensifying bioprocesses. You will learn about: