December 1, 2024
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Sponsored by Bruker
Process Analytical Technology (PAT) can greatly improve the manufacturing of biotherapeutics through monitoring key analytes and process parameters in real time. Compared to offline sampling methods, PAT solutions offer immediate and actionable information to improve control over the process, leading to higher yields of the target protein. High-Throughput Raman Spectroscopy in particular, which is powered by Tornado’s patented High-Throughput Virtual Slit (HTVS™) Technology, is a PAT solution for monitoring cell cultures that provides extremely rapid, accurate, in-situ measurements. Tornado Raman Spectrometers can monitor several key metabolites such as glucose, lactate, protein titer, and more. Learn more about the capabilities of Tornado Spectrometers for your bioprocessing needs!
Key Benefits of Tornado Spectrometers for Biotherapeutics Manufacturing
Superior Performance: In-line, real-time measurements can be challenging to obtain with enough sensitivity and accuracy to be useful. However, Tornado Spectrometers make 10x faster measurements with 3x better measurement quality compared to other Raman spectrometers. This superior performance makes them an ideal solution for developing, optimizing, and monitoring cell culture processes.
Flexible implementation: Tornado Spectrometers can be used for off-line sampling or the in-line monitoring of both batch and continuous processes. They have been developed with compatibility to a wide range of automated bioreactor systems. Plus, fully automated solutions with full loop feedback control due to embedded OPC UA capabilities.
Plug-and-Play Solutions: Model development for bioprocess monitoring can demand time and expertise, which is why we offer easy plug-and-play methods for glucose and lactate monitoring to save you time and effort.
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