|Once an engineering curiosity and smallscale laboratory technique, continuous bioprocessing has evolved in just a few short years to a topic of intense and increasing interest to most bioprocessors. Critics point to a steep learning/adoption curve, but that is nothing new in biomanufacturing.Andrew Zydney is a distinguished professor of chemical engineering at Pennsylvania State University. He has noted these challenges facing continuous processing: commercially unproven unit operations (especially downstream), a lack of equipment robustness, sterility concerns, and uncertain development timelines (1).
Zydney acknowledges that bioprocessors faced similar issues during the dawn of therapeutic biotechnology in the 1980s and then again two decades later with the emergence of single-use processing. ‚ÄúThese issues all relate to change,‚ÄĚ he says. ‚ÄúThe solutions were addressed and answered in batch processing to everyone‚Äôs relative satisfaction. None are insurmountable in continuous mode, but companies must put in the time and effort to address these concerns to new manufacturing platforms.‚ÄĚ
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