Process Intensification and Continuous Bioprocessing: Multistep Multicolumn Chromatography (MS-MCC)

Until now, one chromatography system was needed to execute one chromatography step. With one three-module BioSC® system, three chromatography separations — including viral inactivation (VI) and in-line dilution (ILD) — can be operated simultaneously and continuously. This system is a straightforward switch from several batch skids to a single DSP skid (Figure 1).

One skid performing an entire downstream process from capture to polishing can reduce a facility footprint drastically and decrease costs significantly. One key benefit of using this system is the elimination of steps that do not add value (e.g., intermediate storage), human intervention (safety, batch failure), and equipment such as holding tanks.

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