Biopharmaceutical companies are striving to produce biologics more efficiently with a lower cost point and fewer employees. Most small-scale media and buffer operations are carried out with small bottles of liquid media. But as processes are scaled up to manufacturing levels, that is no longer a viable option. Costs of shipping liquid are simply prohibitive, so the industry has migrated to using media and buffer in powder form. In fact, 90% of cell-culture media and buffer for sale is now in powder form, which needs to be hydrated, mixed, and packaged to be used in bioprocesses. This â€śjust in timeâ€ť hydration allows for increased compliance and process efficiency.
Making biologics safely also means designing a process to reduce contamination risk at every step, even where it may not seem obvious to do so. One often overlooked step is mixing media and buffer powder during a process. It is still common to see people pouring open buckets of powdered media into a mixing tank, with powder flying into the air and around the room. That leads to a dirty environment that is hard to clean and validate. We have found a way to make this process seamless, easy, and safe by using a system that is the state-of-the-art solution in single-use facilities.
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