Author Archives: Ramsey Shanbaky

Application of an Effective In-Line Analytical Instrument for Biopharmaceutical Development and Manufacture

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The rapid advancement and competitiveenvironment of the modern biopharmaceutical industry, accompanied by the need for continuous quality improvement, demand robust analytical instruments. Analytical technology is one key factor contributing to the quality and safety of finished products. Ongoing improvements in analytical instruments are needed to address new challenges, including specificity of target substances, high complexity of matrices, and multiple production stages with a number of input and output parameters and peculiarities. Those factors point to the demand for a versatile…

March 2, 2023

Ask the Expert: In-Line Concentration Measurement for Adaptive Control of Downstream Processes

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In-line process analytical technologies (PATs) hold much promise for enhancing control of biopharmaceutical manufacturing processes and, in turn, increasing process quality and reproducibility. During a January 2022 presentation, Ramsey Shanbaky (associate director of bioprocess applications at Repligen) described how his company’s CTech FlowVPX system for in-line protein concentration measurement enhances monitoring of downstream processes. Shanbaky’s Presentation Scientists often use ultraviolet–visible spectroscopy (UV-vis) to measure protein concentration in a drug substance (DS) or product (DP). Most UV-vis instruments determine that by…

April 18, 2022