Combining Novel Jetting Manufacturing Technology with a New, Alkaline-Stable Protein A Resin

Praesto® Jetted A50 is the first protein A resin to meet the future demands in monoclonal antibody (MAb) processing today. It delivers enhanced performance characteristics through Purolite’s patented manufacturing technology: Jetting. This continuous manufacturing process — combined with a novel, alkaline-stable continuous manufacturing process with a novel, alkaline-stable protein A ligand called NGL Impact A™ (supplied by Repligen Corporation) — results in the only bioprocess-scale agarose available with a uniform particle-size distribution. Compared with other resins, Praesto®
Jetted A50 resin delivers superior performance characteristics such as:

  • Ultrahigh dynamic binding capacity of ~80 g/L
  • Threefold increase in productivity
  • Exceptional alkaline stability for hundreds of cycles
  • Improved flow properties
  • No fines, decreased resin fouling, and improved lifetime
  • Up to 40% reduction in buffer volume
  • 80% reduction in resin costs.

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