Time Is of the Essence: Optimizing Cell Line Development

Cell line development is a critical upstream step for the manufacture of monoclonal antibodies (MAbs). Cells must be engineered to produce a biologic of interest, and the right clone must be selected to deliver material for preclinical and clinical studies. A high-producing cell line is then needed to support clinical studies and, ultimately, commercialization of the therapeutic.

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Corresponding authors are Aurore Poles, Global Technical and Compliance Expert, and Guillaume Plane, Global Development and Marketing Manager; aurore.poles@milliporesigma.com and guillaume.plane@milliporesigma.com. Both focus on BioReliance® End-to-End Solutions at MilliporeSigma.

The life science business of Merck KGaA, Darmstadt, Germany, operates as MilliporeSigma in the United States and Canada.

To learn about our plug-and-play upstream development service, please visit EMDMillipore.com/plug-play-upstream.

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