To Compress or Not to Compress: What You Need to Know About Packing Resins at Process Scale

This webcast features: Dr. Mark A. Snyder, Manager, Process Chromatography, R&D Applications Group, Bio-Rad Laboratories

Join our expert, Dr. Mark A. Snyder, to learn best practices and guidelines for successfully packing different types of chromatography resins. This includes incompressible resins like CHT Ceramic Hydroxyapatite Media as well as traditional compressible resins. CHT is an easy-to-use mixed-mode media and has high specific gravity, a rapid settling rate, and sensitivity to mechanical shear. These variations from traditional compressible resins have to be considered when designing CHT column-packing protocols. In general, parameters such as compression factor, settling rate, and attributes of the base matrix need to be considered when packing resins at process scale. Packing methods can be adapted to obtain simple and the most reproducible packing. Attend this 15-minute webcast and get all your process column-packing questions answered.

Overview

  • Differences between compressible and incompressible resins
  • Slurry preparation techniques
  • Slurry transfer methodologies
  • Column packing guidelines
  • Packed column evaluation and qualification testing
  • A word about height equivalent to a theoretical plate (HETP)

BIO-RAD and CHT are trademarks of Bio-Rad Laboratories, Inc. in certain jurisdictions. All trademarks used herein are the property of their respective owner.

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