Coming to America: WuXi Biologics Expands Again

Dan Stanton, Editorial director

June 11, 2018

3 Min Read
Coming to America: WuXi Biologics Expands Again
WuXi Biologics' first US site will be in Worcester, MA. Image: Wikimedia/Terageorge

WuXi Biologics will construct its first biomanufacturing facility in the US. The US$60 million plant is the third overseas expansion announced in the past month by the Chinese CDMO.

Chinese contract development and manufacturing organization (CDMO) WuXi Biologics has rapidly begun expanding its biomanufacturing capacity. A string of investments over the past few weeks will add new capacity in China as well as see the firm venture overseas, including in the US where a US$60 million (€51 million) plant in Worcester, Massachusetts has just been announced.

“WuXi Biologics has always positioned us as a global company, so opening a site in the global center of biotech [Massachusetts] is a matter of time,” WuXi Biologics CEO Chris Chen told BioProcess Insider. “MA government has been in discussions with us for close to a year and has been supportive.”

The facility will be operational in the fourth quarter 2020, he added, and will employ around 150 staff.

MFG11, as it is to be known, will be the eleventh facility in WuXi’s growing network. Like the others (detailed below), the Worcester facility will be based on fully disposable equipment. It will boast 4,500 L of bioreactor capacity, made up of two 2,000 L traditional fed-batch and one 500 L perfusion-based continuous processing system.

US Environment

This is the third site to be constructed outside of China, following announcements made over the past month to build a similar clinical and commercial 4,500 L facility in Singapore and a 54,000 L facility in County Louth, Ireland.

According to Chen, the decision to move into the US was based on capacity needs, and not recent changes in the US tax and manufacturing landscape.

“Since we planned this site for more than a year, current trade policy does not play a role in decision making. We will increase our capacity globally based on our needs.”

Internal Expansion Vs Acquisition

Experts in the Chinese biomanufacturing space applauded WuXi’s latest movement.

“It makes sense on their part as it simplifies supply chain for contracts in the US,” Matthew Minakowski

senior business development manager of fellow China-based CDMO Mab-Venture Biopharma told us. “The facility presence in the US also reduces potential hesitance of smaller companies who may not want to go to China for CMC development or CMO work.”

He added China has seen other biopharma moving to the US through acquisition – 3S and Therapure, Hepalink and Cytovance, for example – “but WuXi seems to favor internal expansion over acquisition in areas they have the capability such as manufacture.”

Most Ambitious CMO Service Offerings in Industry History

David Deere, founding chief commercial officer of PaizaBio, commented via social media:

“WuXi has embarked on the most ambitious CMO service offerings in industry history, throwing their spear into the ground on three continents and if successfully executed both operationally and commercially, meeting all regulatory hurdles, will seamlessly allow truly global strategic sourcing to meet any client need.”

Deere’s firm  describes itself as a ‘portal of entry’ for Western pharmaceutical companies seeking to enter China. And speaking with BioProcess Insider, he said WuXi’s expansions represent a “very good strategy.”

He continued: “It will use Singapore and the US facility to attract CTM/launch, for eventual commercial production in both US and Singapore, with an option for the client to transfer manufacture to their larger facilities in China or the EU (Ireland).

“In the case of the US, of course, they can always add additional capacity if client wants strictly US domestic production, likely, should Trade discussions impact API with tariffs.”

WuXi Biologic’s Global Network

DS Capacity

MFG1

5,000 L fed-batch/perfusion

2012

Wuxi, China

Commercial

MFG2

28,000 L fed-batch

2,000 L perfusion

2017

Wuxi, China

Commercial

MFG3

5,200 L fed-batch

2018

Shanghai, China

Clinical

MFG4

10,000 L fed-batch

2019

Wuxi, China

Clinical/Commercial

MFG5

60,000 L fed-batch

2020

Wuxi, China

Commercial

MFG6

6 x 1,000 L perfusion

2021

Mullagharlin, Ireland

Commercial

MFG7

48,000 L fed-batch

2021

Mullagharlin, Ireland

Commercial

MFG8

48,000 L fed-batch

2021

Shijiazhuang, China

Commercial

MFG9

4,500 L fed-batch/perfusion

2022

Shijiazhuang, China

Clinical/Commercial

MFG10

4,500 L fed-batch/perfusion

2022

Singapore

Clinical/Commercial

MFG11

4,500 L fed-batch/perfusion

2020

Massachusetts, US

Clinical/Commercial

About the Author

Dan Stanton

Editorial director

Journalist covering the international biopharmaceutical manufacturing and processing industries.
Founder and editor of Bioprocess Insider, a daily news offshoot of publication Bioprocess International, with expertise in the pharmaceutical and healthcare sectors, in particular, the following niches: CROs, CDMOs, M&A, IPOs, biotech, bioprocessing methods and equipment, drug delivery, regulatory affairs and business development.

From London, UK originally but currently based in Montpellier, France through a round-a-bout adventure that has seen me live and work in Leeds (UK), London, New Zealand, and China.

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