New MilliporeSigma Products Bring Ease of Use to Single-Use

Single-Use Mobius 1000L bioreactor

MilliporeSigma is launching three Mobius® products that deliver improved efficiency and ease-of-use for biopharmaceutical manufacturing workflows.

The new Mobius® products include a 1000-liter single-use bioreactor with an industry-leading design, a 2000-liter mixing system for difficult-to-mix biopharm ingredients and a large volume liquid transport system for aseptic and non-aseptic substances.

“Our newest Mobius® products meet our customers’ increasingly complex demands for user friendly systems that allow them to focus on their science,” said Udit Batra, CEO, MilliporeSigma.

The Mobius® 1000 liter single-use bioreactor completes the comprehensive Mobius® stirred tank portfolio of 3 to 2000 liter sizes, delivering greater flexibility and continuity for scale-up. With the industry’s only bottom-loading drawer for easy and safe bag installation, MilliporeSigma’s new bioreactor is designed to achieve homogenous and fast mixing for consistent performance, especially at large scale.

The Mobius® Power MIX 2000 creates a strong vortex to handle difficult-to-mix buffers, media and other biopharm ingredients. Powerful mixing is achieved from an impeller design and motor based on magnetically-coupled NovAseptic® technology, a proven mixing technology in stainless steel tanks. The Power MIX 2000 provides accessible, sterile zero deadleg sampling directly from the mixing container. A Probe Port allows for insertion of either a reusable probe for non-aseptic processes or a pre-sterilized, single-use sensor for in-process pH measurement of aseptic processes.

The Mobius® single-use 3D large liquid transportation system’s single-use bags and stainless steel transporter bins facilitate the safe and convenient road transport of aseptic and non-aseptic media, buffers, in-process intermediates and final bulk drug products at cold or ambient temperatures. The system offers four single-use bag assemblies with working volumes of 100 to 500 liters. All bags are constructed from PureFlex™ Plus film with a proven low extractable profile and gas barrier properties.