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2016 BioProcess International Awards
A New Paradigm in Process Development: To Accelerate Biologic Manufacturing of MAbs, Vaccines, and Novel Biotherapies
Addressing High Demands for Increased Productivity in Downstream Operations
Advances in Single-Use Platforms for Commercial Manufacturing
April 2019 – Smart(er) Facilities for Biomanufacturing
Biopharmaceutical Training Supplement
Bioreactors: Process Advances in Cell Culture and Fermentation
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September 2018 Featured Report: Cell Line Development
State of the Industry – 2017 BioProcess International Special Issue
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Covering the whole development process for the global biotechnology industry

Upstream
Processing
Bioprocessing begins upstream, most often with culturing of animal or microbial cells in a range of vessel types (such as bags or stirred tanks) using different controlled feeding, aerating, and process strategies.
Downstream
Processing
Beginning with harvest of material from a bioreactor, downstream processing removes or reduces contaminants to acceptable levels through several steps that typically include centrifugation, filtration, and/or chromatographic technologies.
Manufacturing
Drug products combine active pharmaceutical ingredients with excipients in a final formulation for delivery to patients in liquid or lyophilized (freeze-dried) packaged forms — with the latter requiring reconstitution in the clinical setting.
Analytical
Many technologies are used to characterize biological products, manufacturing processes, and raw materials. The number of options and applications is growing every day — with quality by design (QbD) giving impetus to this expansion.
Business
Even as it matures, the biopharmaceutical industry is still a highly entrepreneurial one. Partnerships of many kinds — from outsourcing to licensing agreements to consultancies — help companies navigate this increasingly global business environment.

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A Strategy to Remove Formulation Development from the Critical Path During Biologics Development

High-Viscosity Mixing: Choosing the Right System for the Job

Understanding Critical Measurement Parameters in Vaporized Hydrogen Peroxide Bio-decontamination

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The Proper Use of Extractables Data: Aspects Beyond Extractables Measurement

Automating Workflow Solutions, Not Instruments: Engineering Validated Processes for Biologics Screening

China Biopharma Opportunities

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Novo Nordisk Pharmatech: Brand Launch Interview

BioProcess International European Summit 2015 – Speaker Interviews

BPI Revisited: Improving IEX Throughput and Performance with Differentiated Chromatography Sorbents

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Step-wise strategy to address process characterization and late phase development – toward the definition of a standardized approach

Characterization and Lot Release Assays for Antibody Drug Conjugates

Keeping Host Cell Protein ELISAs Covered

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A Platform Production Process for Manufacturing Viral Vector and Vaccine Therapeutics Using Vero Cells

BioProcess Insider BPI Theater @ BIO 2018 Interviews – Tuesday

Manufacturing Automation for Patient-Scale Cell Therapies

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December 2014 Issue Author Insights

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Sponsored Content
The Proper Use of Extractables Data: Aspects Beyond Extractables Measurement
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Integrity Redefined: Consistent Robustness and Integrity Testing Lead to Enhanced Process Integrity and Patient Safety

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RT @Dan5tanton: Another biomanufacturing investment in by WuXi Biologics in native China. But how will #CDMO staff these facilities… https://t.co/jw7KrnnEi1 2 days ago
And a heck of a headline to boot! https://t.co/rU6KXg1NMj 3 days ago
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